Mo - Introduction to personalized medicine / pharmacogenetics /-genomics

Question 1

What does pharmacogenetics study?

Answer 1

Study or clinical testing of specific genetic variation that give rise to differing drugs response, incl. metabolism, disposition, tolerability, and efficacy

Question 2

What does pharmacogenomics study?

Answer 2

Study of the role of the whole genome in drugs response

Question 3

What does SNP stand for?

Answer 3

Single nucleotide polymorphisms

Question 4

What is an SNP?

Answer 4

single nucleotide polymorphisms: DNA variation in which only one nucleotide differs between the reference and the variant

Question 5

What is precision oncology?

Answer 5

Sequencing of genomes in biopsies that barely represent the heterogenous mix of tumor cells and microenvironment cells

Question 6

How can pharmacogenetics help prevent adverse events or improve drug efficacy?

Answer 6

By enabling physicians to optimize dosage or to avoid a medication with adverse reactions and to prescribe an alternative therapy