Th - PET in response monitoring and prediction Flashcards

1
Q

What does the time course and magnitude of uptake depend on in PET pharmacokinetic modelling? (2)

A

Input function and kinetic behaviour of tissue/tumor

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2
Q

What are two challenges in PET kinetic analysis? (2)

A

1.Assessment of most appropriate (accuracy and precision) kinetic model, parametric method or simplified approach
2.Find accurate and non-invasive methods for extracting / obtaining input functions, either plasma input or reference tissue, reduce scan time

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3
Q

Why quantify tracer uptake in PET monitoring? (2)

A

To compare patients, also for longitudinal studies

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