Mo - Phosphoproteonomics for target discovery and personalized medicine Flashcards

1
Q

What is proteomics?

A

Large scale analysis of proteins

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2
Q

True or false: Multiple genomics and post-genomic aberrations determine cancer phenotype

A

True

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3
Q

What is mass spectrometry? What is it used for?

A

The weighing of molecules, used for determining which proteins are which

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4
Q

How is phosphoproteonomics used in cancer? (2)

A

To identify drug targets, to reveal heterogeneity of cancer cell lines

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5
Q

How can phosphoproteomics be used in personalized medicine?

A

To determine which patients have certain kinase mutations and are thus candidates for targeted therapy

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6
Q

How can phosphoproteomics be used specifically in T-cell acute lymphoblastic leukaemia? (Explain complicated)

A

Phosphoproteomics can identify targetable kinases, upon which Inhibition of the INSR/IGF-1R axis can sensitize T-cell acute lymphoblastic leukaemia cells to dastinib treatment

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