Mo - Phosphoproteonomics for target discovery and personalized medicine Flashcards
What is proteomics?
Large scale analysis of proteins
True or false: Multiple genomics and post-genomic aberrations determine cancer phenotype
True
What is mass spectrometry? What is it used for?
The weighing of molecules, used for determining which proteins are which
How is phosphoproteonomics used in cancer? (2)
To identify drug targets, to reveal heterogeneity of cancer cell lines
How can phosphoproteomics be used in personalized medicine?
To determine which patients have certain kinase mutations and are thus candidates for targeted therapy
How can phosphoproteomics be used specifically in T-cell acute lymphoblastic leukaemia? (Explain complicated)
Phosphoproteomics can identify targetable kinases, upon which Inhibition of the INSR/IGF-1R axis can sensitize T-cell acute lymphoblastic leukaemia cells to dastinib treatment