Mo - Dendritic Cell vaccines in acute myeloid leukaemia

Question 1

What kind of CD do Tcyt cells have?

Answer 1

CD8+

Question 2

What kind of CD do Th cells have?

Answer 2

CD4+

Question 3

What kind of cells are impaired in MDS?

Answer 3

Dendritic cells

Question 4

In which ways are dendritic cells impaired in MDS in leukaemia? (2)

Answer 4

Frequency and function

Question 5

What kind of cell source is this dendritic cell from between autologous and allogeneic: DC-leukemia hybrids

Answer 5

Autologous

Question 6

What kind of cell source is this dendritic cell from between autologous and allogeneic: DC-AML cell line hybrid

Answer 6

Allogeneic

Question 7

What kind of T cells do you get with dendritic cell immunotherapy in MDS leukaemia?

Answer 7

Memory T cells

Question 8

What are 6 limitations to DC immunotherapy? (6)

Answer 8

Clinical efficacy unsubstantiated, mutagenicity of tumor associated antigens, invasive procedure, induction to tumor intrinsic factors inducing Treg cells, expression of inhibitory ligands, tumor evasive mechanisms of the tumor microenvironment