WBCs Alterations Flashcards
Hyposegmentation
In the nucleus
Bilobed/Peanut-shaped
Associated W/:
Pelger-Huet
Myeloproliferative
Myelodysplastic
Hypersegmentation
In the nucleus
6+ lobes
Megaloblastic Anemia
Chromic infections
Rarely inherited
Vacuoles
In the plasma
Unstained circular area
Bacterial/fungal infection
Poisoning
Burns
Chemo
Artifacts
Dohle Bodies
Plasm, often near periphery
Gray-blue round or oval body single or multiple
Bacterial Infection
Poisoning
Burns
Chemo
May-Hegglin Anomaly
Pregnancy
Toxic Granulation
Plasm of Neuts, unevenly distributed
Prominent Blue-Black grans,
few-many composed of primary grans.
Bacterial Infections
Poisoning
Burns
Chemo
Pregnancy
G-CSF therapy
Takes place in the Plasm
Decreased-None specific grans
Infections
Myelodysplastic Syndrome
Degranulation
Agranulation
In the plasm
Fused primary grans
Red in color
Single/Multiple per cell
AML and aPML in FAB M1-M6
Auer Rods
Large Azurophilic granules in all cell lines (Most PTs)
Contain mucopolysaccharides due to enzyme deficiencies
Appear abnormal, Function Normal
Alder-Reilly Function
Pince nez
Hyposegmentation
Coarse, clumpy nuclear chromatin
Increased Bands
Pelger-Huet Anomaly
Large Dohle-like bodies in granulocytes and monocytes
Low PLT count W/ Giant PLTs
Abnormal but function normal
May-Hegglin Anomaly
Large-fused granules in granulocytes.
Due to abnormal granule formation
Abnormal and function abnormal
Can’t degranulate
Albinism and silver hair
Chediak-Higashi Anomaly
Normal WBCs
Defective Respiratory burst
Cells engulf, but don’t kill
Recurrent infections
Normal and function abnormal
Chronic Granulomatous disease
What are the pseudo causes of Pelger-Huet?
Leukemia
Drug ingestion
