Chap 17

Question 1

Most common causes of IDA in men and women?

Answer 1

Inadequate Intake

Increased need
(Women during pregnancy)

Impaired Absorption

Hemorrhage

Question 2

Typical PB smear findings?

Answer 2

Microcytic, Hypochromic
Targets, Elliptos, Teardrops
(If due to bleeding, Leukocytosis or Thrombocytosis possible).

Question 3

IDA CBC findings?

Answer 3

Decreased:
RBC, Hgb, Hct, MCV, MCH, MCHC

Normal - Decreased:
Retics

Question 4

IDA BM findings?

Answer 4

Decreased stainable Iron
Mild-Moderate Erythroid hyperplasia
M:E Ratio decreased

Question 5

IDA Chemistry?

Answer 5

Decreased SI and Ferritin

Increased TIBC

Question 6

Anemia of Chronic Inflammation/Disease (ACD)

Answer 6

Anemia occurring in PTs W/ chronic infections, chronic inflammatory disorders, trauma, organ failure, or Neoplasms.

Question 7

Anemia of Chronic Disease occurs due to the biochemical changes during?

Answer 7

Inflammation

Question 8

Hepcidin

Answer 8

Acute phase Reactant

Question 9

Hallmark sign of Anemia of Chronic disease is?

Answer 9

Normal to Increased Ferratin

Question 10

Typical Lab Findings for ACD?

Answer 10

Decreased:
RBC, Hgb, Hct, MCV, MCH, SI Transferrin

Normal to Increased:
Ferritin

Normal:
MCHC

Normal to Decreased:
Retics, TIBC

Question 11

PB Smear of ACD?

Answer 11

Normocytic, Normochromic
Target, Elliptos, Teardrops

Question 12

BM Findings in ACD?

Answer 12

BM M:E Ratio increased

Question 13

Anemias associated W/ Abnormal Heme Synth?

Answer 13

Sideroblastic Anemia (SA)
Lead Poisoning
Porphyria

Question 14

Sideroblastic Anemia (SA)

Answer 14

1st step in heme synth affected.

Question 15

Characteristics of SA?

Answer 15

Increased total body iron
Ringed Sideroblasts in BM
Hypochromic Anemia

Question 16

Classifications of SA?

Answer 16

Hereditary

Acquired

Question 17

2 forms of Acquired SA?

Answer 17

Idiopathic (Unknown)

Secondary Type

Question 18

Causes of Secondary type of Acquired SA?

Answer 18

Certain therapeutic drugs

Chronic transfusions (Aplastic Anemia, Leukemia, Thalassemia)

Alcoholism & food fads

Use of Iron utensils/ Increased Iron in water.

Question 19

SA Mechanism?

Answer 19

Adequate Iron but can’t be incorporated into Hgb Synth.

Question 20

Where does the Iron go in SA, instead of Hgb Synth?

Answer 20

Mitochondria of Metarubricyte, accumulates leading to ringed Sideroblasts.

Question 21

What happens to the mitochondria eventually inside the Metarubricyte in PTs W/ SA?

Answer 21

Ruptures

Question 22

How does lead poisoning cause anemia?

Answer 22

Lead interferes W/ iron storage in the mitochondria.

Damages activity of enzymes used in Heme Synth.

Basophilic Stippling pronounced

Question 23

PB Smear of SA?

Answer 23

PHBs
Hypochromic, Normochromic
Normal to increased PLTs

Question 24

Chemistry of SA PB?

Answer 24

Increased SI and Ferritin

Decreased TIBC

Question 25

Hemochromatosis Lab features?

Answer 25

Increased SI and Ferritin

Decreased TIBC and Transferrin

Question 26

When Microcytic and Hypochromic, cytoplasm appearance?

Answer 26

Defective cytoplasmic maturation

Normal nuclear maturation

Question 27

Regardless of plasm maturation, the main point is?

Answer 27

Decreased Hgb production