RBC variations Flashcards
Acanthocyte (Spur Cell)
H Acanthocytosis
Severe liver disease
Splenectomy
Malabsorption
Hypothyroidism
Vitamin E. deficiency
Burr Cell (Echinocyte, Crenated Cell)
burr-like eryth, W/short evenly spaced projections.
Seen in: Uremia, PK deficiency, Microangiopathic Hemolytic Anemia, Neonates (especially pre-mature), Artifacts.
Spherocyte
Round, W/ no central pallor.
Seen in: H. Spherocytosis, some hemolytic anemias, transfused cells, and sever burns.
Target cells
Associated W/:
Hemoglobinopathies
Thalassemia
IDA
Splenectomy
Obstructive liver disease
Sickle Cells
Homozygous Hgb S Disease
Hb C Crystals
Hexagonal, usually 1 per cell.
Homozygous Hgb C disease.
Hb SC Crystals
1-2 fingerlike projections
Look like a mitten.
Hb SC disease
Stomatocytes
Eryth W/ slit-like area of central power.
H Stomatocytosis
Alcohol
Liver Disease
Rh null phenotype
Artifact
Elliptocytes/Ovalocytes
Elliptos: Cigar-shaped
Ovalos: egg-shaped
Seen in: HE, HO, Thalassemias major, IDA, Megaloblastic anemias (Macro ovalocytes), Myelophthisic anemias.
Teardrop Cell
Eryth in shape of pear.
Myelofibrosis W/ myeloid metaplasia, Thalassemias, Myelophthisic anemias,
Other causes extramedullary Hematopoiesis.
Schistocytes
Fragmented eryth W/ many sizes and shapes.
Seen in:
Microangiopathic Hemolytic Anemia
(Disseminated Intravascular Coag DIC)
Severe burns
Hemolytic uremic syndrome
Thrombotic Thrombocytopenic purpura (TTP)
Renal graft rejection
Rouleaux
Erythrocytes arranged in rows like stacks of coins.
Increased concentrations of globulins and/or paraproteins.
Autoagglutination
Clumping of Eryths.
Ag/Ab reactions
Normocyte
MCV 80-100 fL
MCHC 32-36%
Microcytic
MCV < 80 fL
IDA
SA
Thalassemia Minor
Chronic disease (occasionally)
Lead Poisoning
Hemoglobinopathies (Some)
