Chap 19 Flashcards
Hypoproliferative Anemias
Aplastic Anemia
Disorder/Group of disorders characterized by aplasia in BM.
Destruction by chemical agents or physical factors.
Affects all cell lines.
Aplasia
Failure of tissue/organ to dev normal.
Aplastic Anemia is caused by?
Immune Process (ABs directed against SCs or cell immune mechanism; T-cell suppresses SC proliferation).
In aplastic anemia the BM fails due to?
Immunologically mediated tissue-specific destruction.
4 Secondary causes of Aplastic Anemia?
Infections (EBV,CMV, HIV)
Chemical Agents (Benzene, Insecticides, Weed killers)
Drugs (Chloramphenicol (Abx),(Phenylbutazone (Anti-Inflam), (Chemo Drugs (Busulfan, Vincristine), (Anticonvulsants (Dilantin)
3 Clinical Manifestations of Aplastic Anemia?
Fanconi’s Anemia
Diamond-Blackfan Anemia
Disease (Kidney, Endocrine)
Pure red cell aplasia BM?
RBC precursors in BM decreased
PB findings of aplastic anemia?
Pancytopenia (Decreased WBCs, Hgb, PLTs), No polychromasia or NRBCs, Normal bilirubin
BM findings in Aplastic anemia?
Hypocellular
Increased fat
Decreased Cells
M:E Ratio- 3:1
Normal to Increased Iron (Not used)
Treatment of choice in aplastic anemia?
BM Transplant
If BM transplant isn’t an option, what is offered for aplastic anemia?
Immunotherapy
Congenital form of Pure red Cell aplasia?
Diamond-Blackfan (Defect in Eryth Precursors).
4 causes of acquired red cell aplasia?
Hemolytic Crises
Infection W/ Parvovirus, EBV, Viral Hepatitis
Malnutrition
Certain drugs or Neoplasms
Hemolytic Anemia think
Reduced RBC lifespan
BM Failure Anemia think?
Impaired cell production
