Chap 10 Flashcards
PLTs
What is the primary Regulator of PLT production and maturation?
Thrombopoietin (TPO)
Which CFU do PLTs differentiate from?
CFU-GEMM
Where is TPO made? (Multiple locations)
Liver, Kidney, Spleen, and Smooth muscle cells
When a PT has an increased PLT count, what happens to TPO?
More TPO is bound, which prevents stimulation of BM progenitor cells.
PLT Functions
*Maintain hemostasis & capillary integrity.
*PLT to PLT interactions
*PLT to Coag protein interactions
*Aid in injuried-tissue healing.
When a vascular injury occurs, what do PLTs do?
Adhere- to the injuried vessel.
Aggregate- spiny spheres that interact W/ each other (PLT plug).
Consolidate- fibrin into a clot.
Stabilize- W/ aid from coag factor.
Thrombopoiesis
production of thrombocytes (PLTs).
Of the 3 stages of maturation during Thrombopoiesis, which is the 1st recognizable?
Megakaryoblast
Characteristics of Megakaryoblast?
20-45um
Plasm blue scanty, pseudopodia
No grans
Nucleus is single, round, indented
Central or Eccentric
Reddish purple
Multilobed Nucleus
NCR-4:1
A megakaryoblast divides by what process?
Endoreplication
Endoreplication is?
The nuclear material reduplicates, but does not divide.
Promegakaryocyte
Basophilic plasm W/ few azurophilic grans and a indented or bilobed nucleus. Ranging in size from 20-80um.
Megakaryocyte
Largest Cell in the BM.
30-100um
Plasm is pinkish-blue and abundant, W/ irregular border and abundant grans.
Nucleus is lobulated, purple W/ granular chromatin.
NCR-1:1-1:2.
When a megakaryocyte reaches full maturation what happens?
Plasm fragments resulting in 1000-2000 PLTs released into the blood and the nucleus is phagocytized.
Thrombocyte (PLT)
1-4um
Plasm is light blue W/ fine grans
No nucleus present
70% are in circulation and 30% stored in the Spleen.
