WBC disorders

Question 1

in hodgkin lymphoma, ____ is used to determine treatment and prognosis

Answer 1

staging

Question 2

initial manifestation of hodgkin lymphoma

Answer 2

enlarged, painless, superficial lymph node

Question 3

the majority (85%) of NHLs are ____ of _____; the remainder are of ____

Answer 3

clonal neoplasms; B lymphocytes; T cell origin (15%)

Question 4

a lymphoma develops when there is a ____ expansion of lymphocytes that have been _____ or have acquired a _____ that alters growth regulation) at a particular stage in transformation

Answer 4

monoclonal; arrested; genetic alteration

Question 5

in NHL, ____ and _____ are better correlated with prognosis

Answer 5

cell type; tumor proliferative index

Question 6

in NHL, prognosis is often based more on the _____ than stage ; _____ is critical with NHL

Answer 6

sub-type of lymphoma; grading/subtyping

Question 7

circulating lymphoma cells in the peripheral blood, associated with NHL, represent a _____ of the disease, in distinction to the group of diseases classified as leukemias

Answer 7

leukemic phase

Question 8

leukemias are malignant neoplasms of _____ that arise in the _____

Answer 8

hematopoietic tissue; bone marrow

Question 9

in AML, _____ is found in the cytoplasm and _____, when present, are diagnostic

Answer 9

myeloperoxidase; cytoplasmic inclusions called Auer rods

Question 10

_____ is most predictive of prognosis in AML

Answer 10

karyotype

Question 11

_____ can manifest in soft tissues in AML

Answer 11

granulocytic sarcoma