neuro path Flashcards

1
Q

most common cause of primary parenchymal hemorrhage

A

hypertension

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2
Q

as vessel walls weaken, rupture and hemorrhage is the most common in the regions of:

A

the basal ganglia, followed by pons, thalamus, and cerebellum

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3
Q

signs/symptoms of intraparenchymal hemorrhage

A

severe headache, hemiparesis, and hemisensory loss

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4
Q

most subarachnoid hemorrhages arise at _____ due to rupture of vessels in _____

A

arterial bifurcations of the circle of willis; the arachnoid space

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5
Q

chief complaint of subarachnoid hemorrhage

A

“worst headache of my life”

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6
Q

ruptured _____ is the most common cause of non-traumatic subarachnoid hemorrhage

A

berry (saccular) aneurysm (of major brain arteries)

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7
Q

vascular malformations are most commonly from _____ in developing brain

A

abnormal angiogenesis

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8
Q

types of vascular malformations

A

arteriovenous malformation (AVM), cavernous angioma, capillary telangiectasias, and venous angioma

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9
Q

collection of abnormal blood vessels of variable caliber; most common type of vascular malformation; most likely to result in intraparenchymal and/or subarachnoid hemorrhages

A

arteriovenous malformations

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10
Q

most common route by which microbes reach the brain

A

hematogenous spread

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11
Q

infections resulting in inflammation of the leptomeninges (arachnoid and pia mater) and subarachnoid space; characterized by purulent exudate under subarachnoid space (over cerebral hemispheres) and within the ventricles

A

acute bacterial meningitis

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12
Q

acute purulent meningitis caused by:

A

pyogenic bacteria (E. coli, group B strep, H. influenza, n. meningitis)

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13
Q

chronic leptomeningitis caused by:

A

both bacterial (m. tuberculosis) and fungal (c. neoformans) organisms

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14
Q

> 2-3 weeks of headache, lethargy, nausea and vomiting; CN palsies and epilepsy; gelatinous exudate, may appear nodular

A

tuberculous meningitis (chronic meningitis)

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15
Q

caused by spherical budding yeast, found in soil and bird excrement; low grade fever, debility and headache; slimy exudate, capsular material

A

cryptococcal meningitis (chronic meningitis)

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16
Q

50% of brain abscesses are spread from _____; ____ is the most commonly identified organism

A

adjacent infections (dental root, ear, sinus)- also spread hematogenously; streptococcus milleri

17
Q

diffuse inflammation of the brain parenchyma caused by a number of viral agents; usually fatal without treatment

A

encephalitis (HSV most common)

18
Q

seen microscopically in encephalitis

A

perivascular lymphocytosis, microglial nodules, and neuronophagia; may also note viral inclusions like Cowdry A (in HSV) and negri bodies (in rabies)

19
Q

autoimmune (T-cell mediated), demyelinating disease; most common demyelinating disease of the brain

A

multiple sclerosis (MS)

20
Q

common manifestations of MS include:

A

visual disturbances, speech and gait abnormalities, paresthesias, and emotional disturbances

21
Q

characteristic lesion of MS- irregular area of demyelination

22
Q

MS plaques can arise anywhere in the brain and spinal cord but most common sites are _____ and _____

A

periventricular white matter; optic nerve

23
Q

microscopically, MS plaques demonstrate areas of demyelination, accomp. by ____ and _____

A

perivascular lymphocytosis; infiltration by foamy macrophages

24
Q

most common cause of dementia in the elderly; increasing incidence with increasing age

A

alzheimer’s disease

25
alzheimer's disease characterized by ____ and _____
brain atrophy (loss of volume and weight); dilation of the ventricular system
26
microscopically seen in alzheimer's disease
neuritic (senile) plaques and neurofibrillary tangles
27
degeneration of the dopamine secreting pigmented neurons of the substantia nigra in the midbrain; unknown etiology
parkinson disease
28
intracytoplasmic, eosinophilic inclusion bodies within pigmented neurons of the substantia nigra and locus ceruleus- diagnostic of Parkinson's disease
Lewy bodies
29
hereditary, progressive disorder characterized by spontaneous, involuntary movement called chorea and also dementia
Huntington's disease
30
etiology of huntington's disease is mutations in the ____ located on the short arm of chromosome 4
huntingtin gene
31
Huntington's disease is characterized by atrophy of:
the basal ganglia