environmental diseases Flashcards
factors affecting chemical injuries
CLADME: concentration, liberation, absorption, distribution, metabolism, and excretion
3 notable adverse drug reactions
- aspirin (acetylsalicylic acid or ASA)
- acetaminophen (tylenol)
- exogenous estrogens and oral contraceptives
lead has a high affinity for enzymes involved in the synthesis of ____ which blocks or hinders the incorporation of ____ into the molecule; this causes patients to develop a ______
hemoglobin; iron; microcytic hypochromic anemia
a wound produced by scraping or rubbing leading to removal of a superficial layer of skin
abrasion
bruise; a wound caused by a blunt object, doesn’t break the skin but may lead to damage of BVs and extravasation of blood in tissues
contusion
a tear in tissue- usually with irregular, jagged edges
laceration
forms of radiation
- electromagnetic waves- x-rays and gamma rays
2. high energy neutrons and charged particles (alpha and beta particles, protons)
unit that expresses amount of energy absorbed by target tissue
gray (Gy)
roughly equal to Gy, but dose also factors in relative biologic effect (RBE)
Sievert (Sv)
changes in the skin with radiation
erythema (redness)- 2-3 days
edema (2-3 weeks)
blistering and desquamation (4-6 weeks)
atrophy, fibrosis, and cancers (months-years)
_____ and ____ are very susceptible to radiation
hematopoietic; lymphoid tissues
___ decrease in hours (rebound in weeks/months), ____ shrink in size, _____ decrease over 1-2 weeks and rebound in 2-3 months; ___ and ____ also decrease but take longer to rebound
lymphocytes
lymph nodes; spleen
granulocytes
platelets and RBCs
lethal range of radiation in humans begins at about ____ and death is certain without medical care at ____ exposure
2 Sv; 7 Sv
3 fatal acute radiation syndromes
- hematopoietic
- gastrointestinal
- cerebral
when a diet is deficient in 1 or more components
primary malnutrition
supply is adequate, but there may be a problem with absorption, storage, utilization, excessive losses, or drug effects
secondary malnutrition
common in developing countries and up to 25% of children affected; causes morbidity in children < 5 years old
protein-energy malnutrition (protein-calorie malnutrition)