Vitamins and minerals Flashcards

1
Q

water sol vitamin ex

A

B-complex group and vit C

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2
Q

water sol vitamins

A

dissolve in water
easily excreted in the urine
cant be stored in the body over long periods
daily intake required to prevent deficiencies
act as coenzymes or oxidation reduction agents

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3
Q

fat sol vitamins

A

in plant and animal foods
stored in the liver
slow metabolism
excreted via feces
toxic in excess
daily intake not required unless deficient

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4
Q

fat sol vitamins ex

A

A D E K

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5
Q

vitamin A

A

aka retinol, retinyl palmitate, retinyl acetate
fat soluble
food surces: liver, fish, dairy, egg yolks, dark leafy greens, yellow-orange veg
comes from carotenes

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6
Q

vitamin A functions

A

growth and development of bone and teeth
night and normal

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7
Q

vit a indications

A

-dietary supplement for infants, pregnant, nursing women
- deficiency (hyperkeratosis, night blindness)
- skin conditions (acne, psoriasis, keratosis follicularis

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8
Q

isotretinoin and vit a

A

result in additive effects and possible toxicity

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9
Q

vit a toxicity

A
  • irritability, drowsiness, vertigo, delirium, coma, vomiting, diarrhea
  • increased intracranial pressure in infants
  • peeling of skin and erythema
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10
Q

vit d

A

-fat sol vitamin
-responsible for utilization of calcium and phosphorus
- vit d2 (ergocalciferol), plant vit d, through dietary
- vit d3 (cholecalciferol) produced by skin by UV irradiation

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11
Q

vit D2 containing foods

A
  • fish liver oils, saltwater fish
  • fortified foods: milk, bread, cereals
  • animal livers: tuna, eggs, butter
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12
Q

vit D functions

A
  • works with parathyroid hormone to regulate absorption and use of calcium and phosphorus
    -for normal calcification of bone and teeth
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13
Q

vit D indications

A
  • treatment of conditions related to long term deficiency (rickets, tetany, osteomalacia)
  • prevention of osteoporosis
  • treats osteodystrophy, hypocalcemia, hypoparathyroidism, pseudohypoparathyroidism, hypophosphatemia
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14
Q

vit D toxicity

A
  • hypertension, dysrhythmias, weakness, fatigue, headache, drowsiness
  • anorexia, dry mouth, metallic taste, nausea, vomiting, constipation
  • decreased bone growth, bone pain, muscle pain
    -polyuria, albuminuria, increased blood urea nitrogen
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15
Q

vit D toxicity can lead to _____ and ___ if untreated

A

impaired renal function and osteoporosis

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16
Q

vitamin E

A

fat soluble
- alpha, beta, gamma, delta tocopherol
- dietary sources: fruits, grains, fortified cereal, veg oil, wheat germ, nuts
- animal sources: eggs, chicken, meat, fish

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17
Q

vit E functions

A
  • unknown
  • antioxidant?
  • no benefit from vit E supplementation
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18
Q

vit E indications

A

dietary supplement
antioxidant
treatment of deficiency ( in premature infants)

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19
Q

vit E adverse effects

A

GI and CNS

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20
Q

vit K 3 types

A

fat soluble
-phytonadione (K1), menaquinone (K2), menadione (K3)
- K2 synthesized by intestinal flora

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21
Q

dietary source of vit K1

A
  • green leafy veggies, cheese, soybean oils
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22
Q

vit K functions

A

blood coagulation factors in the liver

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23
Q

vit K indications

A
  • treats deficiency states (antibiotic therapy and newborn malabsorption)
  • prophylactically to newborns
  • reverse effects of warfarin
  • pts become unresponsive to warfarin 1 week after vit K admin
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24
Q

vit B1 (thiamine)

A

water sol
food sources: enriched whole grain breads and cereals, liver, beans, yeast
deficiencies: beriberi, wernicke’s encephalopathy

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25
Q

Beriberi

A
  • brain lesions
    -polyneuropathy of peripheral nerves
  • serous effusions
  • cardiac anatomical changes
  • cerebral berberi: wernickes encephalopathy
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26
Q

vit b1 (thiamine) functions

A

-increase metabolism/pathways(kerbs)
- maintains PNS, cardio system, GI tract

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27
Q

vit B1 (thiamine) indications

A

-treats beriberi, peripheral neuritis, neuritis of pregnancy
- metabolic disorders
- malabsorption
- management of poor appetite, UC, chronic diarrhea, cerebellar syndrome or ataxia
- oral insect repellant?

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28
Q

vit B2 (riboflavin)

A
  • water sol
  • food sources: leafy greens, eggs, dairy, nuts, legumes, meats, liver, yeast, enriched whole grains
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29
Q

vit B2 causes of deficiency

A
  • alcoholism
  • intestinal malabsorption
  • long standing infections
  • liver disease
    -malignancy
  • probenecid therapy
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30
Q

vit B2 functions

A
  • converted into 2 coenzymes essential for tissue respiration
  • required to activate vit B6
  • tryptophan -> niacin
  • maintains erythrocyte integrity
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31
Q

vit b2 deficiency

A

-cutaneous, oral and corneal changes
- cheilosis (chapped or fissured lips)
- seborrheic dermatitis
- keratitis

32
Q

vit B2 indications

A

-supplement
-microcytic anemia
- acne
- migraine

33
Q

vit B2 adverse effects

A

large doses: discoloured orange urine

34
Q

vit B3 niacin

A

water sol
-food sources: beans, turkey, tuna, liver, yeast, peanuts, enriched whole grain bread and cereal, wheat germ
- synthesized from tryptophan

35
Q

vit B3 functions

A

converted to nicotinamide
nicotinamide is converted to 2 conenzymes
enzymes req for gylcogenolysis and tissue respiration and carb, lipid, protein and pruine metabolisim

36
Q

vit B3 indications

A

prevention and treatment of pellagra
management of dyslipidemia
beneficial effects in peripheral vascular disease

37
Q

vit B3 deficiency

A

pellagra
- mental: psychotic sympt
- neurological: neurasthenic synd
- cutaneous: crusting, erythema, desquamation of skin, scaly dermatitis
- inflammation of mucous mem
- gi: bloody diarrhea

38
Q

vit B3 adverse effects

A

flushing pruritus and GI distress

39
Q

vit B6 (pyridoxine)

A

water sol
- sources: whole grains, wheat germ, yeast, fortified cereals
- fish, organ meats, poultry, meat, eggs
- peanuts, nuts, veg, bananas

40
Q

vitamin B6 functions

A
  • for metabolic functions (protein, lipid, carb utilization, conversion of tryptophan to niacin
  • integrity of peripheral nerves, skin, mucous mem, hematopoietic system
41
Q

vit B6 deficiency

A
  • sideroblastic anemia
  • neurological disturbances
    -seborrheic dermatitis
  • cheilosis
  • xanthurenic aciduria
42
Q

causes of vit B6 deficiency

A
  • inadequate intake
  • poor absorption
  • uremia, alcoholism, cirrosis, hyperthyroidism, malabsorption, HF
  • drug induced: isoniazid for TB, hydralazine for hypertension
43
Q

vit B6 indications

A
  • vit B6 deficiency
  • seizures that are unresponsive to normal therapy
  • morning sickness from preg
  • pts with various metabolic disorders
44
Q

vit B6 toxicity

A

with large doses
neurotoxicity

45
Q

vit B12 (cyanocobalamin)

A

water sol
- synthesized from microorganisms present in the body
- food sources: liver, kidney, fish, shellfish, poultry, milk, eggs, blue cheese, fortified cereals

46
Q

vit B12 function

A
  • fat and carb metabolism
  • protein synth
  • growth and cell replication
  • hematopoiesis
  • nucleoprotein and myelin synthesis
47
Q

vit B12 deficiency

A
  • most common: pernicious anemia - deficiency leads to: neurologic damage and megaloblastic anemia
  • caused by: malabsorption, poor dietary intake of animal organ foods
48
Q

vit B12 oral absorption

A
  • requires presence of intrinsic factor
  • intrinsic factor: glycoprotein secreted from gastric parietal cells
49
Q

Vit C (ascorbic acid)

A

water sol
- from citrus, strawberries, tomatoes, potatoes, broc, spinach, brussel sprouts, cabbage, green pepper, liver
- can be synthesized

50
Q

vit C functions

A
  • oxidation reduction reactions
  • req for several metabolic activities - collagen synthesis
  • maintenance of connective tissue
  • tissue repair
  • maintenance of bone, teeth, capillaries
  • folic acid metabolism
  • erythropoiesis
    -enhanced absorption of iron
  • cellular resp
  • resistance to infect
51
Q

vit C deficiency

A

-prolonged: scurvy
- weakness, gingivitis, loss of teeth, anemia, subcut hemorrhage, anemia, subcut hemorrhage, bone lesions, delayed healing of soft tissue and bones, hardening of leg muscles

52
Q

vit C indications

A
  • prevention of scurvey
  • urinary acidifier
  • no value of prophylactic for common cold
53
Q

vit C megadoses

A

nausea, vomiting, headache, adb cramps
- acidified urine, stone formation
- discontinuing megadoses: scurvy like sympt

54
Q

The most abundant mineral in the body

A

Calcium

55
Q

What is required for efficient absorption of calcium

A

Vitamin D

56
Q

Calcium requirements high for:

A

Growing children
Women who are pregnant or breastfeeding

57
Q

Food sources of Calcium

A

Especially milk and dairy products
Fortified cereals
Calcium-fortified orange juice
Sardines, salmon

58
Q

What is calcium used for

A

Transmission of nerve impulses
Contraction of cardiac, smooth, and skeletal muscles
Renal function, respiration, and blood coagulation
Maintains cell membrane and capillary permeability

59
Q

What does hypocalcemia look like

A

Infantile rickets (weakening of bones)
Adult osteomalacia
Osteoporosis

60
Q

Causes of calcium deficiency

A

Inadequate intake of calcium or vitamin D
Hypoparathyroidism
Malabsorption syndrome

61
Q

What does hypercalcemia cause

A

Anorexia
Nausea
Vomiting
Constipation
If severe
Heart irregularities
Delirium
Coma

62
Q

How does chelation affect calcium

A

Chelation bind to calcium and cause a insoluble complex

63
Q

Hypercalcemia + Digoxin=

A

serious cardiac dysrhythmias

64
Q

What is magnesium needed for

A

Nerve function
Muscle contraction

65
Q

Dietary sources of magnesium

A

Green leafy vegetables
Meats, seafood, milk, cheese, yogurt
Bran cereal, nuts
(need more if protein-rich foods, calcium, and phosphorus)

66
Q

Causes of hypomagnesemia

A

Malabsorption
Alcoholism
Long-term intravenous feedings
Diuretics
Metabolic disorders (hyperthyroidism, diabetic ketoacidosis)

67
Q

Hypomagnesemia signs and symptoms

A

Anticonvulsant in magnesium deficiency
Pre-eclampsia and eclampsia
Tocolytic drug for inhibition of uterine contractions in premature labour
Pediatric acute nephropathy
Cardiac dysrhythmias
Constipation (short-term treatment)

68
Q

Adverse effects of Hypermagnesemia

A

Tendon reflex loss
Difficult bowel movements
CNS depression
Respiratory distress
Heart block
Hypothermia

69
Q

Dietary sources of phosphorus

A

Milk, yogourt, cheese
Peas, meats, fish, eggs

70
Q

Phosphorus Deficiency causes

A
  • Rarely dietary causes
    Malabsorption
    Extensive diarrhea or vomiting
    Hyperthyroidism
    Long-term use of aluminum or calcium antacids
    Liver disease
71
Q

Functions of phosphorus

A
  • Required precursor for the synthesis of essential body chemicals
  • Responsible for cellular energy transfer
  • Necessary for the development and maintenance of the skeletal system and teeth
72
Q

Phosphorus aids in synthesis of

A

Nucleic acid
Adenosine diphosphate
Adenosine monophosphate
Adenosine triphosphate

73
Q

Adverse effects of phosphorous

A

Diarrhea
Nausea and vomiting
Other GI disturbances
Confusion
Weakness
Breathing difficulties

74
Q

What is zinc used for

A
  • Essential in metabolic reactions of proteins and carbohydrates
  • Important for normal tissue growth and repair, especially wound repair
75
Q

Where is Zinc found

A

Red meats, liver, oysters, milk products, eggs, beans, nuts, whole grains, fortified cereals, certain seafoods