Viruses of childhood Flashcards
atypical measles
intense rash, vesicles, petechiae, prurpura or urticaria
erythema infectiosum =
parvovirus B19
RotaTeq vaccine
life attenuate vaccine, human bovine reassortant,
oral, 3xbetween 2, 4 6 months
parvovirus B19 complciations
anemia due to reduced cell number and hemoglobin
aplastic crisis due to RBC loss
transmission to fetus > still brith, edam (detal hydrops) anemia, CHF, no abnormalities
subacute sclerosing panencephalitis
measles
CNS perosnality, behavior memory changes
myoclonc jerks, spasticity
blindness
newly discovered parvovirus resposnible for repiratory and GI infections
bocavirus
parvovirus internalized via
coated pits
parvovirus B19 clinical
eryhtma infectiosum (fifths disease)
red cheeks, maculopapu;ar rash
circulating immune complexes > rash, athralgia, arthritis, but do not fix complement
congenital rubella syndrome
cataracts
heart defects
deafness
growth + mental retardation
FTT
mortality
microencephaly
key to meales, mumps, rubella vaccination effectiveness
single antigenic type (infection prevents reinfection)
systemic replication prior to infecting target ogan - antibodies can limit or block at this stage
measles pathogenesis
respiration
lymphatic spread > viremia
conjunctivae, respiratory, urinary tract, vessels, lymph, cns
Virus infected endothelial cells plus immune Tcells
Rash
Recovery + immunity
post measeles encephalitis
acute onset of headache, vonfuion, voimitiung, coma after rash dissipates
major enterovirus groups resonsible for paralytic disease, encephalitis meningitis, RTI, undifferenciated fever
Poliovirus,
coxsackie A and B virus
Echnoviruses
parvovirus infection location, recepotr
actively replicated RBC progenitors in marrow (viremia)
receptor is blood gorup P antigen (globoside)
antigen group of Rota virus most common cause of human disease
group A (VP6 subgroup)
rubella (german measles) =
togavirus
targets for norovirus therapy
protease, viral pomyerase
structural porteins target for virus like particle Vaccines
chicken pox =
varcilla zoster virus
norovirus reinfection due to
lack of lasting immunity, strain diversity
enterovirus pathogensis
fecal/oral or resp
rplication in oropharynx and GI
viremic phase to target tissue (antibody can block before(
possible secondary viremeia
Rotatrix vaccine
live attenuated singel human strain
oral 2x 2 and 4 months
mumps clinical sypmtoms
parotitis
swelling of glands (ochrtitis, mastitis, pancreatitis, throiditis)
CNS involvement
(mild meningitis and rare encephalitis)
rare outcomes measles
post-infectious encephalitis
subacute sclerosing pnenncephalitis (CNS)
no resolution of acute infection caused by defective CMI (often fatal)
entero toxin of rotavirus, role
NSP4 - receptor on cells > signaling events lead to increase in intracellular Ca >> tight junction interference
also stimulates enteric nerves > stimulate goblet cells > stmulate Cl release >diarrhea
Parvovirus replication requirements
host S phase
uses cellular DNA pol
rotavirus virology
11 ds RNA segements, 12 genes
no envelope
3 layer capsid
multple antigenic groups A E
hand foot, mouth disease, viruses and symptoms
Coxsackie A and Enterovirus 71
mild fever, sore through
vesicular lesions
fatigue and loss of apeptite
MMR measles mumps rebella vaccine
live, attenuated combination
blocks virus during systemic stage and prevents infection of target organ
symptoms measues
cough, conjunctivitis, coryza, photpobia, koplik spots
(otitis media, croup pneumonia, blindness, encephalitis complications)
rubella virology
togavirus, only infects humans
one serotype
adult meningitis symptoms
headache
fever chills
nausea vomiting
still meck light sensitiity
roseola (exanthem subitum) =
human herpes virus 6
measles (rubeola) =
paramyxovirus
parvovirus B19 morphology
ss DNA virus
nonenveloped iscosohedral
replicates in nuclues
dependent on host DNA replciation
infant symptoms meningitis
fever
irritability
poor eating
hard to awaken
mumps pathogenesis
resp epithelium
local replication and viremia
infection of parotid gland and CNS
inflammation adn swelling > sweeling of other glands
pancrease (associated with juvenile diabetes?)
