Oncogenesis

Question 1

integration disrupts expression of ___ gene, (a transcriptional repressor) allowing increased levels of E6 and E7

Answer 1

E2

Question 2

Papilomavirus genes E1 and E2 code

Answer 2

replication and transcription of vial DNA

Question 3

Papilomavirus E5 codes

Answer 3

stimulates constitutive growth factor receptor signaling

Question 3

when Cdk/cyclin had accumulated in G1, ____ becomes phosphorylated and inactivated, allowing progression to S phase

Answer 3

Rb

Question 5

inappropriate entry into cell cycle can activate ____ inducing production of Cdk/cyclin inhibitors to stop cell cycle

Answer 5

p53

Question 6

E6 Papilomavirus protein recruits ubiquitan ligase that targets __ for degradation, preventing it from blocking progression into S phase or inducing apoptosis

Answer 6

p53

Question 7

Papilomavirus genes L1 and L2 code

Answer 7

capsid

Question 7

high risk strains of HPV tend to show

Answer 7

enhanced E6 E7 activity

Question 8

___ of Papilomavirus induces expression of telomerase

Answer 8

E6

Question 9

Papilomavirus genes E6 and E7 code

Answer 9

neutralize major brakes that regulate cell cycle (p53 and Rb) uncoupling cell division from control

Question 10

Papilomavirus genes E4 code

Answer 10

disrupts cytokeratines to facilitate virus egress from tissue

Question 12

E7 protein of Papilomavirus binds ____ and targets it for proteosomal degradation

Answer 12

Rb

Question 13

HPV causes cell replication in ___ while typically only stratum basale cells replicate

Answer 13

stratum spinosum

Question 14

Papilomavirus life cycle tied to what host factor

Answer 14

differentiation state of keratinocytes