VIral infections in transplant Flashcards
common pre-engraftment infection, fever, diffuse rashi, can only diagnose via PCR of blood
herpes virus 6 HHV6
varicella infection window in transplant
beyond day 100
BK polyomavirus persists in (cell types)
most lkely promixal renal tubular cells
also lymphocytes and others
polymaviru small T antigen role
alter activity of cellular protein phosphatase
J domain of LT antigen role
DNA replication
CMV infection window in transplant
typically post engraftment
polymavirus tropism defined by
host cell surface gangliosides
JC polyomavirus persists in (cell types)
kidney, lymphocytes, bone marrow
Varicella infection secondary to reactivation commonly comorbid with
herpes zoster or primary chicken pox
only polyomavirus classified as causative agent of human malignancy
Merkel cell polyomavirus
polymavirus LXCXE role
binds and disrupts tumor suppressor proteins RB, p130, p107 > promotes cell proliferation
role of miRNA in polymavirus genome
shuts off early genes
early hemorrhagic cystitis associated with
late onset hemmorrhagic cystitis after day 15 from
early = cyclophosphamide primary to transplant
late due to DK JC virus, or adenovidurs
disease BK polyomavirus BKPyV
nephropathy in renal transpplant
BMT-hameorrhagic cystitis
induces tumors when inoculated into experimental animals
Adenovirus infection symptoms in transplant
URI
Diarrhea,
Conjunctivitis,
Cystitis,
Rash
hepatitis
neurologic disease
