Lytic viruses

Question 1

picornavirus physical properties

Answer 1

iscosahedral, +ssRNA, no lipid envelop, no tegument

Question 2

poliovirus entry and genome release

Answer 2

injection into cytoplasm (nucleus not involved)

Question 3

inapparent subclinical poliro

Answer 3

90-95% of infections, asymptomatic, virus from throat or stool

Question 3

piconavirus diagnosis

Answer 3

isolation in CSF, stool, culture. Serum 4 fold rise in titer. PCR

Question 3

genome, adenovirus

Answer 3

double stranded, unenveloped genome

Question 4

picornavirus prevention mechanism Ribavirin

Answer 4

RNA depedent RNA polymerase inhibitors

Question 5

paralytic poliomyelitis

Answer 5

asymmetric flaccid paralysis, lower extremities especially, bulbar paralysis, slow recovery with residual paralysis

Question 7

aseptic meningitis, nonparalytic polio

Answer 7

minor progresses to CNS, stiff back and neck, 2-10 days then complete recovery

Question 8

virus of common cold

Answer 8

rhinovirus

Question 9

virus associated with gastroenteritis, myocarditis, encephalitis

Answer 9

Parechovirus

Question 11

adenovirus diease

Answer 11

URI and occular > ecephalitis> GI and LRI > sytemic >genitourinary. 3-10 incubation, 6-9 days diarrhea

Question 12

picornavirus prevention mechanism ruprintrivir

Answer 12

target protease processing

Question 13

picornavirus prevention mechanism pleconaril

Answer 13

prevent entry and genome release

Question 14

Mild polio

Answer 14

minor undifferentiated febrile illness, URI, influenza like

Question 15

virus associated with paralysis, polio, common cold, meningitis, diarrhea, hand-foot-mout

Answer 15

enteroviruses

Question 16

vvirus associated with hepatitis

Answer 16

hepatoviruses

Question 17

virus associated with gastroenteritis

Answer 17

Kobuvirus