Respiratory Viruses

Question 1

Rinovirus genus

Answer 1

picornaviurs

Question 2

antigenic shift

Answer 2

infrequently, at hemagglutinin alone or neuraminidase as well

Question 2

symptoms of rhinovirus due to

Answer 2

inflammatory response bradykinin and histamine

Question 2

parinfluenza virus (mumps virus)

Answer 2

paramyxovirus

Question 3

SARS and MERS-CoV are caused by

Answer 3

coronaviruses

Question 4

respiratory adenovirus injections can lead to

Answer 4

systemic infection, destructive productive infection or latent infections

Question 5

parainfluenza virus, tends to be asymptomatic or mild

Answer 5

HPIV4

Question 7

second most prevalent cause of common colds, URI,

Answer 7

Coronaviruses

Question 7

measles virus enus

Answer 7

morbillivirus

Question 7

HN protein (hemagglutinin attachment an neuramindadase) not present in

Answer 7

RSV

Question 9

two emerging respiratory viruses with high mortality rates, jump from bats to people in Australia and Asia

Answer 9

Paramyoxvirade Hendra and Nipah viruses

Question 10

hendra, nipa genus

Answer 10

henipavirus

Question 12

Orthomyxovirus genus

Answer 12

Thogovirus

Question 13

complications of influenza virus infection

Answer 13

primary viral pneumonia, 2nd bacteria pneumonia, myositis and cardiac involvement, neurologic syndrome (Guillain barre, encephalopahty, encephalitis)

Question 13

most common cause of fatal acute respiratory tract infection in infants and youn children, reinfection occur throughout life, ubitquitous

Answer 13

Paramyoxviridae - respiratory syncytial virus

Question 15

antigenic drift

Answer 15

minor changes in hemagglutinin or neuroamindidase or both, resulting from mutations

Question 17

pathogenesis Resipratory syncytial virus (paramyoxvirdae)

Answer 17

syncintia with mutli-nucleated giant cell, giant cell death leads to accumulation in airways leading to pathology

Question 17

severe disease in infants/elderly/immunnocompromsied, pumonary disease and COPD, by age 5, all children seropositive. Second most common cause of RTI after RSv

Answer 17

Human metapneumovirus hMPV

Question 18

acute influenza infection in adults

Answer 18

rapid fever, malaise, myalgia, sore throat, nonproductive cough

Question 19

non structural proteins in paramyoxovirus family modulate immune response in vivo

Answer 19

NS1 and NS2

Question 20

Influenza pathogenesis

Answer 20

infects ciliarted epithielial cells in upper respiratory > cell damage due to virus activated CTL (viremia not a major role)

Question 21

parainfluenza virus, tend to infect later in life and common cause of croup

Answer 21

HPIV1 and 2

Question 23

similar to respiratory syncytial virus RSV, common cause of LRI including bronchitis in first year of life (a parainfluenza virus)

Answer 23

HPIV3

Question 24

common cause of acute and lower RI in infants, young children, elderly and immunocompromised

Answer 24

Human parainfluenza viruses

Question 25

family, hemmaglutinin and neuroimindase activity on single protein (virlal attachment and release)

Answer 25

Paramyovirus

Question 26

paramyoxovirus genome

Answer 26

ss negative RNA

Question 27

acute influenza infection in children

Answer 27

higher fever than adults, GI symptoms, ortitis media, myositis, more frequent croup

Question 28

maternal infection protect infant protection in RSV? (paramyoxvirdae)

Answer 28

no

Question 29

most important in limiting reinfection of rhinovirus

Answer 29

secretory IgA

Question 30

disease mechanism respiratory syncytial virus (paramyoxviridae)

Answer 30

localized to resp tract, penumonia from cytopathologic spread of virus, narrows airways of infants, bronchiolitis mediated by host response

Question 31

respiratrtory syncytial virus, metapneumovirus genus

Answer 31

penumovirus