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Immune Micro 3 > Lymphotropic viruses > Flashcards

Lymphotropic viruses Flashcards

1
Q

presentation cytomegalovirus persistent infections

A

atherosclerosis, immunosenescence, neuroblastoma

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1
Q

CMV does not encode ____ making acyclovir ineffective

A

thymidine kinase

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1
Q

HHV-6b replication in

A

CD4 Tcells (latency site unknown)

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1
Q

EBV latency II displays ___ antigens

A

EBNA1, LMP1, LMP2A, RNA EBER&2

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1
Q

HHV8 Kaposis sarcoma gamma herpesvirus replication in

A

CD19 B cells, endothelial cells, monocytes, keratinocytes, epithial cells

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2
Q

Herpesvirus 6b HHV-6b genome

A

dsDNA

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3
Q

congentialCMV permanent symptoms

A

hearing loss, vision loss, retardation, musculoskeletal abnormalities, seizures, septal defects

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4
Q

Beta herpes viruses

A

cytomegalovirus Herpevirus-6a, Heprevirus-6b, Herpevirus-7

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4
Q

viral characteristics cytomegalovirus

A

dsDNA, immediate, early, late stages of gene expression. Enveloped, icosahedral nucleocapsid, tegument proteins and RNA

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4
Q

serology of EBV, identify heterophile antibodies via

A

capability to agglutinate animal RBCs

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6
Q

CMV symptoms at birth

A

lesions, small size, hepatosplenomegaly, jaundice, hemolytic anemia, pneumonia, intracranial calcifications, microcephaly

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7
Q

CMV lytic replication in

A

epithelial, dendritic, fibroblast, smooth muscle, endothelial, macrophages, trophoblast

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9
Q

EVB mediated B cell proliferative disease activated by immunosuppression

A

Post transplant lymphoproliferative disorder

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10
Q

presentation cytomegalovirus health adults

A

asymptomiatic in healthy adults (mild mononucleosis)

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11
Q

EBV disease

A

infectious mononucleosis, Post transplant lymphoproliferative disorder, Lymphomas (B, T and NK cell)

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12
Q

presentation cytomegalovirus - birth defects

A

mental retardation, deafness, death

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13
Q

EBV lymphoma, EBV DNA in epithelial tumor cells, China, alska, tunisa and E Africa

A

Nasopharyngeal epithelia carinoma

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14
Q

HHV8 disease

A

Kapsosi sarcoma endothelial derived neoplasm, primary effusion lymphoma, multicentric Castleman disease

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15
Q

cytomegalovirus latency in

A

macrophages

16
Q

gamma herpes viruses

A

Epstien Barr, Kaposi’s Sacrcoma virus

17
Q

EBV latency II and III

A

viral antigens made in memory B cells, can lead to Burkits, Hodkin lymphoma, nasopharyngeal carcinoma

18
Q

EBV mono results from rapid proliferation of

A

atypical T cells, (downey cells)

19
Q

EBV transmission

A

saliva and blood, limited to epitheliam of pharynx and bcells due to restricted cellular expression

20
Q

Treatment CMV

A

Granciclovir or valganciclovir OR Foscarnet OR Cidofovir

21
Q

HHV 8 charactersitics

A

dsDNA, common in Africa

23
Q

immune response to CMV

A

innate macrophage/NK/IFN response insufficient. Humoral does not clear but can limit reinfection or reactivation. Cytotoxic Tcells kill CMV infected cells (immune response cannot completely control)

24
Q

EBV latency I displays ___ antigens

A

EBNA1 RNA EBER&2

26
Q

cytomegaalovirus transmission

A

semen/cervical secretion/blood/milk/tears/urine/feces/saliva./transplacental

27
Q

EBV lymphoma in immunosupressed and trasplant patients

A

Polyclonal lymphoma, lymphocytic interstitial pneumonia, Hairy oral leukoplakia of the tongue

28
Q

EBV ___ tethers viral genome to host chromosome

A

EBNA1

29
Q

EBV lymphoma, B cell lympomas

A

Hodkin and non-Hodgkin lymphoma

31
Q

epstein barr, kaposi’s sarcoma virus latency in

A

plasma cells

33
Q

primary infection EBV mono due to

A

robust expansion of Tcells, atypical or Downey Tcells

34
Q

EBV latency I

A

antigens made in proliferating B ells, infectious mono, post transplant lymphoproliferative disorder

35
Q

gamma herpes virus HHV-8 =

A

Kaposis sarcoma herpesvirus

36
Q

EBV dissemination phase, B cells produce

A

heterophile antibodies (non functional)

37
Q

cytomegalovirus shedding starts at

A

1 month post infection, can last months - 1 year

37
Q

CMV infection symptoms

A

fever, fatigue, sore throut, liver function abnormalities, lymphocytosis, lymphadenopathy, mononucleosis (heterophile antibody negative)

39
Q

EBV, loss of T cell function results in ____ diseases

A

b cell proliferation of disease

40
Q

HHV-6b clinical disease

A

exanthem subitum or roseola infantum, fever, malaise, lympadenopathy, rash after fever break, no sequalae

41
Q

mononucleosis in CMV infection is ___ antibody negative

A

antibody negative

42
Q

cytomegalovirus infected cells show

A

owl eye, inclusion body

43
Q

Ebstein Barr virus characteristics

A

dsDNA, nucleocapsid, tegument and envelope with glycoproteins, 3 stage gene expression

44
Q

EBV lymphoma, B cell lymphoma of jaw and face, children 5-10, IgG promoter myc proto-oncogene, Associated with chromosomal translocation

A

Burkitt’s lymphoma

45
Q

Roseolovirus (HHV-6) latency in

A

T-lymphocytes

46
Q

diagnosis CMV

A

IgM testing variable, IgG avidity increases with time to define primary infection and recent vs past. Viral DNA, culture and immunofluorescence

47
Q

CMB latent infection in

A

CD34+ hematopoeitic progenitor cells, monocytes

Immune Micro 3 (17 decks)

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