Hepatitis Flashcards
immunity to Hep A
no chronic infection, infection confers lifelong immunity
tissue culture system for Hep B
none
virology Hep E
enteric virus
calicivirus family
+sense single strand RNA
icosahedral
chronic Hep C infection prone to hepatic carcinoma because
core protein interacts with p53, Rb tumor suppressors and pathways involved in proliferation
core protein induces steatosis
envelope protein inhbits natural NK cells
non-structural proteins can enhance cell growth
steatosis in Hep C
core protein induces lipid accumulation leading to fatty acid spiral > oxidative stress and cell Proliferation > accerated HCC
tissue culture system Hep A
none
entrance of Hep D (delta agent) increaes liklihood of
fulinant hepatitis
transmission Hep A
fecal oral
Hep B virions enveloped and released with
shedding of surface antigens
Hep A viral shedding occurs
before symptoms emerge
rare complcations, chronic sequelae Hep A
fulminant hepatitis, cholestatic hepatits, relaspsing hepatitis,
no chronic sequela
role in Hep B HCC “x protein”’
decreaes p53 guardian of genome activity
Hep B chronic infection occurs in
infants
Clinical presentations Hep B
Fever, rash arthritis
Jaundice
dark urine
Malaise, Anorexia, nausea, RUQ pain
serotypes Hep A
single serotype
Hep D virology
virioid
small RNA copid by host RNA pol II
encodes 1 antigen, packages in Hep B sAg
Hep C liverr damage due to
viral replciation inducing robsust innate immune resposne
once naive lymphocytes have responded with 10-15 cell divisions, they must
rest, and can be stimualted to proliferate again later (principle of boosters)
outbreaks of hep E due to
contaminated water
Nonfectious particles produced by Hep B infected cells
HbsAg particles
reccodmended for Hep A vaccination
infants
travels to HIV area
Chronic Liver disease
working with HAV
Hep A vaccine
inactivated with formalin
cell culture grown in human fibroblasts
aluminum adjuvant
___ and ___ eliminate Hep A infected cells, Ab response assists in viral clearance
NK and cytotoxic T cells
Hep C infection requires ___ that regulates mRNAs in a sequence specific manner, the most common enhancing translation and replication
miRNA
hep B virus receptor
sodium/bile acid cotransporter (NTCB)
Genome-wide association study pointed to ___- gene in outcome of HCV infection
IL28 B, econdes antiviral cytokine IFN lambda
Hep A virology
+ strand icosahedral
RNA virus
Capsid stable to acid, drying detergens
incubation period hep B
2 months
Hep D, clinical features (2 courses)
Coinfection - severe acute disease and low risk of chronic infection
superinfection (later infection with Hep B - chronic infection likely, high risk severe chronic liver disease
Hep __ rearranges intracellular mmebranes as a platform for replication
Hep C
Hep C encodes multiple ____ enable virus persistancee
immunomodulaters
Hep C virus often associated with cellular ___-
VLDL
Hep C virology
flavivirus
pos stran RNA
enveloped proteins
Error prone polymerase
effective cell-mediated response to hep B leads to
acute disease and resolution
Virology Hep B (Hepadnavirus)
enveloped
circular DNA genome, partly double strnaded
mRNA reverse transcribed to partially DS DNA
chonic Hep B causes hepatocellular carinoma because
liver injury > cell proliferation > viral DNA in host DNA causes genomic instability
virally encoded X protein
Hep D can only grow in
Hep B infected Cells
Hep A incubation period
30 days
