Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Immune Micro 3 > Hepatitis > Flashcards

Hepatitis Flashcards

1
Q

immunity to Hep A

A

no chronic infection, infection confers lifelong immunity

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
1
Q

tissue culture system for Hep B

A

none

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

virology Hep E

A

enteric virus

calicivirus family

+sense single strand RNA

icosahedral

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

chronic Hep C infection prone to hepatic carcinoma because

A

core protein interacts with p53, Rb tumor suppressors and pathways involved in proliferation

core protein induces steatosis

envelope protein inhbits natural NK cells

non-structural proteins can enhance cell growth

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

steatosis in Hep C

A

core protein induces lipid accumulation leading to fatty acid spiral > oxidative stress and cell Proliferation > accerated HCC

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

tissue culture system Hep A

A

none

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

entrance of Hep D (delta agent) increaes liklihood of

A

fulinant hepatitis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

transmission Hep A

A

fecal oral

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Hep B virions enveloped and released with

A

shedding of surface antigens

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Hep A viral shedding occurs

A

before symptoms emerge

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

rare complcations, chronic sequelae Hep A

A

fulminant hepatitis, cholestatic hepatits, relaspsing hepatitis,

no chronic sequela

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

role in Hep B HCC “x protein”’

A

decreaes p53 guardian of genome activity

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Hep B chronic infection occurs in

A

infants

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Clinical presentations Hep B

A

Fever, rash arthritis

Jaundice

dark urine

Malaise, Anorexia, nausea, RUQ pain

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

serotypes Hep A

A

single serotype

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Hep D virology

A

virioid

small RNA copid by host RNA pol II

encodes 1 antigen, packages in Hep B sAg

15
Q

Hep C liverr damage due to

A

viral replciation inducing robsust innate immune resposne

16
Q

once naive lymphocytes have responded with 10-15 cell divisions, they must

A

rest, and can be stimualted to proliferate again later (principle of boosters)

17
Q

outbreaks of hep E due to

A

contaminated water

17
Q

Nonfectious particles produced by Hep B infected cells

A

HbsAg particles

18
Q

reccodmended for Hep A vaccination

A

infants

travels to HIV area

Chronic Liver disease

working with HAV

19
Q

Hep A vaccine

A

inactivated with formalin

cell culture grown in human fibroblasts

aluminum adjuvant

20
Q

___ and ___ eliminate Hep A infected cells, Ab response assists in viral clearance

A

NK and cytotoxic T cells

21
Q

Hep C infection requires ___ that regulates mRNAs in a sequence specific manner, the most common enhancing translation and replication

A

miRNA

22
Q

hep B virus receptor

A

sodium/bile acid cotransporter (NTCB)

23
Q

Genome-wide association study pointed to ___- gene in outcome of HCV infection

A

IL28 B, econdes antiviral cytokine IFN lambda

24
Q

Hep A virology

A

+ strand icosahedral

RNA virus

Capsid stable to acid, drying detergens

25
Q

incubation period hep B

A

2 months

26
Q

Hep D, clinical features (2 courses)

A

Coinfection - severe acute disease and low risk of chronic infection

superinfection (later infection with Hep B - chronic infection likely, high risk severe chronic liver disease

28
Q

Hep __ rearranges intracellular mmebranes as a platform for replication

A

Hep C

29
Q

Hep C encodes multiple ____ enable virus persistancee

A

immunomodulaters

31
Q

Hep C virus often associated with cellular ___-

A

VLDL

32
Q

Hep C virology

A

flavivirus

pos stran RNA

enveloped proteins

Error prone polymerase

33
Q

effective cell-mediated response to hep B leads to

A

acute disease and resolution

35
Q

Virology Hep B (Hepadnavirus)

A

enveloped

circular DNA genome, partly double strnaded

mRNA reverse transcribed to partially DS DNA

36
Q

chonic Hep B causes hepatocellular carinoma because

A

liver injury > cell proliferation > viral DNA in host DNA causes genomic instability

virally encoded X protein

37
Q

Hep D can only grow in

A

Hep B infected Cells

38
Q

Hep A incubation period

A

30 days

Immune Micro 3 (17 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions