Neurotropic viruses Flashcards
varicella zoster pathogensis
replication in Tcells, epithelial, endothelial >> Latency in widespread ganglia >> viral gene products translated in neuron >> secondary viremia
diagnosis herpes varicella zoster
acute pain, DNA PCR, detections of VZV antigens in lesions via immunofluorescence
lytic life cycle alpha genes
immediate genes - manipulate cell cycle
treatment herpes virus
nucleoside analog drugs - acyclovir (no HSV vaccines, only for varicella zoster)
Varicella zoster vaccine, characteristics
live, attenuated virus Oka Strain
hand herpes dermatitis
herpes whitlow
lytic life cycle gamma genes
late genes, code for virion structural components
Beta herpes viruses
Cytomegalovirus, Roseolovirus, HHV-7
prevention neonatal herpes
drugs prior to birth to supress viral reactivation
circular viral DNA is associated with host ____ and maintained as a ____
with host nucleosomes (via chromatin) and maintained as an episome
gamma herpes viruses length ofreplication cycle, latency location, host range
slow replication cycle, latency in lymphocytes and myeloid cells. Limited host range
dermatitis of athletes in contact sports
herpes galdiatorium
beta herpes viruses length ofreplication cycle, latency location, host range
long replication cycle, latency in secretory glands, lymphoreticular system, kidney. Limited host range
herpes-linked blindness
herpes keratitis and conjunctivitis
incubation period varicella zoster
10-21 days
alpha herpes viruses characteristic
short replication cycle, latency in sensory ganglia, broader host range
gamma herpes viruses
Epstein Barr, Kaposi’s Sarcoma virus
herpes varciella zoster basic clinical disease
chicken pox primary infection, blisters, itching, fever, malaise. secondary infections (pneumonia, skin infection, CNS)
site of latency HSV 1 and 2
HSV 1 - trigmeninal ganglion, HSV-2 splanchnic
alpha herpes viruses
HSV, Varicella zoster virus
lytic life cycle beta genes
early genes - code DNA synthesis machinery
defining properties herpes viruses (3)
Encode enzymes involved in nucleotide metabolism, DNA synthesis, and protein kinase. AND Synthesis of DNA and capsid in nucleus, rest of virion in cytoplasm. AND 2 life cycles: lytic and latency
diagnosis herpes
vesicles at site of inoculation, clinical virology (HSV antigens, PCR) serology to determine infection status
spread herpes varicella zoster
skin to skin - aerosolized fro mlesions and respiratory tract
herpes varicella zoster Hepes zoster clinical presentation
reactivation of VZV from sensory ganglia, prostherpetic neuralgia (severe pain without vesicualr lesion, last for moths without relief)
varicella zoster vaccine impact
reduces severity of primary infection, can still reactivate later in life but with mild symptoms.Immunization later in life limits zoster
