Host response Flashcards
IL 12 promotes
NK producition of IFNy, differentiation to Th1
viruses encode ___ to inhibit apototic cascade 4
viral Bcl-2, vTNF-Rs, p53 inhibitors, v-vaspase inhibitors
TNF factor induces ___ and ____
fever and death signaling
IFNa/b signaling occurs at___ to activate ___
JAK/STAT pathway receptors to activate PKR and 2’5’oligoadenylate synthase
____ encode its own strucutred RNA binds to PKR and inhibits activation by dsRNA
adnovirus
modes of impacting MHC and NK ligand expression (4)
block tap transporter to prevent MHC folding in ER AND bind class I and cause retrotranslocation to ER and degradation AND bind class I in ER and prevent translocation to golgi AND bind class I in ER and route to lysosome
NK cell activity enhance by
IFNs and IL-12
NK cell kills after assessing balance between 2 signals
inhibitory signals from class I, activating signals from NK activating ligands
PKR phosphorlates ___ which deactivates its dilivery of Met tRNA to ribosome, preventing protein translation
elF-2a
IFN a used in treatment of
chronic hep c
pox viruses encode dsRNA binding proteins that sequester dsRNA and prevent
PKR activation
OAS is activated by ___, which catalyzes synthesis of oligo adenylate from ATP which activates ____ an endoribunuclease to degrade mRNA
OAS is activated by double-stranded RNA, which catalyzes synthesis of oligo adenylate from ATP which activates RNAse L an endoribunuclease to degrade mRNA
IFN b used in treatment of
MS
POx viruses encode ____ that bind PKR and prevent it from phosphorylating elF2a
elF2a decoy
pro inflammatory cytokines 3
TNF, IL-1B, IL-6
