Virulence factors Flashcards
What is virulence
capacity of a microbe to cause damage to host
what is adhesin
enables binding of organism to host
what is invadin
enables organism to invade host
what is impedin
enables organism to avoid host defence
What is aggressin
causes damage to host directly
What is modulin
induces damage to host indirectly
Name some virulence factors
Fibrinogen binding protein, leukocidin and TSST-1
What is Panton Valentine Leukocidin
Toxicity for leukocytes, assoc severe skin infections
What disease is the TSST-1 super antigen associated with?
Toxic shock
How would you diagnose necrotising pneumonia
fever, macular rash and desquamation, hypotension, more than 3 organs involved
What causes impetigo, cellulitis, necrotising fasciitis
Strep pyogenes
Is impetigo contagious
YES
What two organisms can cause toxic shock
Strep pyogenes- invasive and staph aureus- localised
