Photocarcinogenesis Flashcards
What is carcinogenesis
process by which a normal cell because a malignant cancer cell
What are oncogenes
gain of function
What are tumour suppressors
loss of function
What factors can cause carcinogenesis
DNA damage, UV exposure, inherited defects
Is UVA direct or indirect DNA damage
Indirect- penetrates more deeply into skin
UVB is less harmful true or false
False- x1000 more damaging
What happens in UV induced immunosuppression
dendrites lose ability to present antigens
What virus is a factor of skin cancer
HPV
Name some phytotoxic drugs
NSAIDS, voriconazole (antifungal), Thiazide diuretics, azathioprine
What is treatment choices for premalignancy
Cryotherapy, surgery, topical agenices, photodynamic therapy