Pharmacology Flashcards
What is the keratin layer also called?
Stratum corneum- important in drug penetration
What is the layer composed of?
Corneocytes surrounded by lipids which are constantly being shed
What are the 2 types of routes
Transcellular and intracellular (convoluted route- most common)
What do corneodesmosomes do?
Join adjacent corneocytes together
What is a topical route
One where a drug is applied directly to surface of skin
What is Ficks law
Rate of absorption (J)= Permeability coefficient (Kp) times Conc of drug in vehicle (Cv)
What is another way of writing this equation
J= (DKm/L)X Cv where D is diffusion coefficient, Km is partition coefficient and L is length of diffusion pathway
Cv and Km are dependent upon vehicle, true or false
TRUE
What are included to enhance solubility of absorption
Excipients
What can improve drug absorption into stratum corneum
Cling film, prevention of water loss, ointment as opposed to cream
Discuss some features of Glucocorticoids
Anti inflammatory, immunosuppresant, vasoconstricting and anti-proliferative with keratinocytes and fibroblasts. Used in atopic eczema
How does the subcutaneous route work
Drug delivery by needle into the subcutaneous fat beneath the skin. Reaches systemic circulation via lymphatics, bloodstream, capillaries
What are advantages of using subcutaneous route?
Protein drugs, slow absorption, oil based drugs can be used.
Why would you use transdermal drug delivery
GTN patch, nicotine. Use in a patch attached to epidermis. In potent, lipophilic drugs. Painless. GN patch, nicotine
