Drug eruptions

Question 1

Are allergic mediated reactions dose dependent or not

Answer 1

Not dose dependent

Question 2

What are most drug eruption presented as

Answer 2

Exanthematous- a rash accompanying a fever or disease

Question 3

How do exanthematous eruptions present

Answer 3

itch, fever, 4-21 days after first taking drug, symmetrically distributed. Can be oedema, SOB, purpura

Question 4

Name some drugs associated with exanthematous eruptions

Answer 4

Penicllins, cyclosporin, erythromycin, NSAIDS, anti-epileptics

Question 5

What is urticarial rash

Answer 5

IgE mediated after B lactic antibiotics or direct release of inflammatory mediators from aspirin, NSAIDS, opiates

Question 6

Which drug does acne arise form

Answer 6

Glucocorticoids and androgens

Question 7

What do fixed drug eruptions present as

Answer 7

red, swollen, symmetrical itch lesions. Due to paracetamol, doxycycline, NSAIDS

Question 8

Which test would you do for suspected allergic contact dermatitis

Answer 8

Patch testing

Question 9

What test would you use for allergic reactions

Answer 9

Skin prick

Question 10

How do you manage drug eruptions

Answer 10

Stop drug, topical steroid, antihistamines, allergy bracelet