Virology (hepatitis viruses) Flashcards
1
Q
What are signs and symptoms of all hepatitis viruses
A
episode of fever, jaundice and increase in ALT and AST.
2
Q
HAV
Asymptomatic, acute, alone
- Virus
- Transmission
- carrier
- incubation
- HCC risk
A
- RNA picornavirus
- fecal oral
- no
- short
- no
3
Q
HBV
- Virus
- Transmission
- carrier
- incubation
- HCC risk
A
- DNA, hepadnavirus
- parental, sexual, maternal
- Yes
- Long (months)
- Yes, it integrates into the host genome, acts like an oncogene.
4
Q
HCV
- Virus
- Transmission
- carrier
- incubation
- HCC risk
- 4 Cās
A
- RNA flavivrius
- Primarly blood (IVDU, post transfusion)
- Yes
- Long
- Yes, chronic inflammation
- Chronic, cirrhosis, carcinoma, carrier
5
Q
HDV
- Virus
- Transmission
- carrier
- incubation
- HCC risk
- Notes
A
- RNA, Delta virus
- Parental, sexual, maternal
- Yes
- Incuabtion
- Superinfection (get HBV then you get HDV)
- Co-infection (get HBV with HDV)
- No
- Defective virus dependent on HBV ā> superinfection dec prognosis
6
Q
HEV
- Virus
- Transmission
- carrier
- incubation
- HCC risk
- Notes
A
- RNA hepevirus
- fecal oral
- No
- Short
- No
- High mortality in pregnant women, Enteric, Expectant mothers, epidemic
7
Q
In HBV, the DNA polymerase has both DNA and RNA depedent activities.
Describe the Entry, Host RNA polymerase, and DNA polymerase functions.
A
- Entry
- Upon entry into the nucleus, the polyerase functions to complete the partial dsDNA
- Host RNA polymerase
- transcribes the mRNA from the viral DNA to make the viral proteins
- DNA polymerase
- reverse transcribes the viral RNA to DNA (which helps form new viral particles).
8
Q
What is best used to detect active hepatitis A.
A
Anti-HAV (IgM)
IgM antibody to HAV
9
Q
What protects against reinfections?
A
Anti-HAV (igG),
IgG antibody indicates prior HAV infection and or prior vaccination
10
Q
what indicates HBV infection
A
HBsAg
Antigen found on surface of HBv
11
Q
What indicates immunity to HBV?
A
Anti-HBs
Antibody to HBsAg
12
Q
What is the antigen associated with the core of HBV
A
HBcAg
13
Q
What is the antibody to HBcAg during
- acute/recent infection
- prior exposure or chronic infection
- This antibody is positive during what?
A
- IgM
- IgG
- Positive during the window period
14
Q
- What is a second different antigenic determinant in the HBV core
- what does it indicate
A
- HBeAg
- Indicates active viral replication adn therefore high transmissibility
15
Q
What indicates low transmissibility?
A
Anti-HBe
