viral hepatiti Flashcards
How is Hep A, Hep B, Hep C, Hep D and Hep E transmitted?
Hep A= Ass
-Faecal oral route
Hep B
-Blood, body fluids, babies (vertical(
Hep C
-Blood
Hep D
-Cannot exist without Hep B
Hep E
-Faecal oral route
Type of virus causing Hep A, Hep B, Hep C, Hep D and Hep E?
Hep B= DNA
Hep A, C, D, E= RNA
what types of hepatitis have a vaccine for them?
Hepatitis A and hepatitis B
management of Hep A?
supoprtive
Management of hep B?
supportive/ antivirals
Management of hepatitis C?
Direct acting antivirals e.g. Sofosbuvir & Daclatasvir 8-12 weeks
Management of hepatitis D?
pegylated interferon alpha for 48 weeks
management of hep E?
supportive
most common hepatitis in the world?
hepatitis A
-however not so common in UK
most common cause of hepatitis E in uk?
eating undercooked pork (faecal oral transmission)
how is hepatitis A diagnosed?
Diagnoses is based on IgM antibodies to hepatitis A
Amy (hep A) knows Molly (IgM) who got it from eating a wrap (contaminated water + food)
what is a rare complication of hepatitis A?
Acute liver failure (fulimant hepatitis)
what types of hepatitis are a notifiable disease?
all of them
what types of hepatitis can cause the 3 C’s as a complicaiton?
and what are the 3 C’s?
Hep B, C + D
3 C’s= cirrhosis, chronic hepatitis + hepatocellular carcinoma
can hep B be spread through breast milk?
no
what antibodies/ antigens are tested to screen for Hep B?
HbcAB
-tests for past or current infection C=core= BB c= infeCtion
HbsAg
-Tests for active infection
what does HbeAg test for in hep B?
High infectivity
what does HbsAg test for in Hep B?
active infection
what does HBcAb, HbcAb IgM and HbcAbIgG test for?
HbcAb tests for past or current infection
HbcAb IgM= acute infection (IgM= iMmediate)
HbcAb IgG= chronic infection (IgG= ghost= chronic)
what tests for for direct count or viral load of Hep B?
HBV DNA (hep b virus DNA)
when is the Hep B vaccine given?
it (HbsAg) is given as part of the 6-in-1 vaccine
Occurs at 2,3 and 4 months
what should be done if a mum is positive for hep B and gives birth to her baby?
Hep B vaccine +HBIG < 12 hours from birth
A further Hep B vaccine at 1-2 months and 6 months
what should be done if someone gets a needle stick injury from hep B source
Give answers for both a responder (anti-HBs >10) + a non responder (anti-HBs<10)
Responder (anti-HBs>10)= booster vacine
Non responder (anti-HBs<10)= Hep B immunoglobin + booster vaccine
how may filimant hepatitis/ acute liver failure present?
very acute deterioration
-Jaundice
-Ascites
-Pain in RUQ
-Sleepiness
-Confusion + disorientation
-N+V
-Breath with a musty or sweet odor
-Tremors
