Viral & Bacterial Pathogens of the Haemolymph System Flashcards
Hemolytic anemia is the…
most common infectious anemia
Hemorrhagic anemia may be caused by…
blood-sucking parasites
Decreased production of RBC causing anemia is usually due to
a chronic infection
What are the 4 main causes of hemolytic anemia in cattle?
- Babesiosis
- Bacillary hemoglobinuria
- Leptospirosis
- Anaplasmosis
Inadequate production of RBC causing anemia in cattle may be due to…
Chronic BVDV
Johne’s Dz
Chronic infections like enzootic bovine leukosis
What common pathogen causes anemia in sheep?
Mycoplasma ovis
What diseases cause anemia in pigs?
- Leptospirosis
- Mycoplasma suis
What diseases cause anemia in horses? Are they bacterial, viral, or both?
- EIA (viral)
- Equine ehrlichiosis (bacterial)
What organisms cause anemia in dogs?
- Mycoplasma hemocanis
- Ehrlichia canis
What diseases cause anemia in felines?
- FIA
- FeLV
- FIV
What pathogens cause anemia in poultry?
- Chick Anemia Virus
- Aegyptianella pullorus
How do you diagnose infectious causes of anemia?
- find agent by PCR or immunofluorescence
How do you control infectious causes of anemia?
- Vx for some
- Txt for some
What organisms cause FIA?
- Mycoplasma hemofelis
- Possible (M. hemominutum, M. turicensis)
How is FIA transmitted?
- Biting arthropods
- young toms biting, fighting
- intrauterine/colostrum
- blood transfusion
What clinical signs might you see in acute FIA?
fever, jaundice, anemia, splenomegaly
What clinical signs might you see in chronic FIA?
weakness, emaciation, anemia
Concurrent infections of what diseases may occur w/ FIA?
FeLV or FIV infections
FIA cats are considered…. after they recover.
Long-term carriers
How would you diagnose FIA?
- serial blood smears (insensitive)
- PCR
- Hematology (regen. anemia)
How would you control FIA?
- choose blood donors carefully
- treat w/ antibiotics
What organism causes bacillary hemoglobinuria?
Clostridium hemolyticum
how would you diagnose Bacillary hemoglobinuria?
- Liver impression smear on PME w/ FA staining
- PCR
Coagulopathy due to hemorrhagic anemia can lead to what two conditions?
- DIC
- Thrombocytopenia
Overwhelming viral and bacterial infections can lead to what aspects of DIC?
endotoxemia, vasculitis
What conditions in cattle might develop hemorrhagic anemia?
- posterior vena caval thrombosis
- Mycotoxins
- Heartwater
- Anthrax
What conditions in sheep might develop hemorrhagic anemia?
- Bacillary hemoglobinuria
- Bluetongue
- Anthrax
What conditions in horses might develop hemorrhagic anemia?
Mycotoxins
EVA
EIA
African horse sickness
E. Equi/Anaplasma phagocytophilum
What conditions in the dog might develop hemorrhagic anemia?
Lepto
infectious canine hepatitis
canine monocytic ehrlichiosis
Canine cyclic thrombocytopenia
Rocky mountain spotted fever
What diseases cause splenomegaly in ruminants?
- Salmonellosis
- Lymphosarcoma
- Anthrax
- Anaplasmosis
What diseases cause splenomegaly in pigs?
- Salmonellosis
- African Swine fever
- Eperythrozoon suis
What infectious diseases cause splenomegaly in horses?
- Salmonellosis
- EIA
What diseases cause splenomegaly in the cat?
- Lymphosarcoma
What is lymphadenitis?
inflammation of the LN
What is lymphangitis?
inflammation of lymphatic vessels
What is lymphadenopathy?
swelling of LNs
What conditions in cattle might cause lymphadenitis, lymphangitis, &/or lymphadenopathy?
Cutaneous actinobacillosis
TB
Enzootic bovine leukosis
What conditions in sheep and goats might cause lymphadenitis, lymphangitis, &/or lymphadenopathy?
Caseous lymphadenitis
Tick pyemia
Tularemia
What conditions in horses might cause lymphadenitis, lymphangitis, &/or lymphadenopathy?
Strangles
Tularemia
Strep spp.
Sporotrichosis
Farcy
Ulcerative lymphangitis
Epizootic lymphangitis
What conditions in cats might cause lymphadenitis, lymphangitis, &/or lymphadenopathy?
Feline leukemia
Feline plague
Tularemia
What is the mechanism for leukopenia?
- direct damage to circulating leukocytes
- effects on production in the bone marrow, LN, Thymus
What organism causes tick-borne fever in ruminants?
Anaplasma phagocytophilum
What is the vector for tick-borne fever in ruminants?
Ixodes sp.
What organisms cause tick-borne fever in horses?
Anaplasma phagocytophilum, Ehrlichia equi
Which occurs in canine parvovirus: leukopenia or neutrophilia?
Leukopenia
What tissues are affected in feline panleukopenia?
- Bone marrow
- thymus
- lymphoid tissue
What disease may cause leukosis/lymphoproliferative disease in cattle?
- Enzootic bovine leukosis
What disease(s) might cause feline leukosis or lymphoproliferative diseases?
Feline leukemia/sarcoma virus
What disease(s) might cause leukosis or lymphoproliferative diseases in poultry?
Avian leukosis
Marek’s
What are the 4 subgroups of feline leukemia?
- FeLV-A: natural transmission, replication competent
- FeLV-B: recombination
- FeLV-C: maturation
- FeLV-T: genetic insertion causing change to envelope protein
What are non-neoplastic clinical signs of FeLV?
Immunosuppression
Anemia
Enteritis
Reproductive failure
What are neoplastic clinical signs of FeLV?
lymphoid/lymphosarcoma
myeloid
thymic lymphoma
Name 2 fungi that are pathogens of the hemolymphatic system?
Sporothrix schenkii
Histoplasma farciminosum