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Hemolymphatics > The Thrombon > Flashcards

The Thrombon Flashcards

1
Q

What is hemostasis?

A

stoppage of blood loss from an injured blood vessel

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2
Q

Define vascular spasm:

A

vessels shrink to prevent blood leaks

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3
Q

What is a platelet plug?

A

when platelets stick together around a wound to patch a leak

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4
Q

What causes clot formation?

A

coagulation proteins, platelets, Ca2+, tissue factors

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5
Q

What are the 5 main steps of platelets forming a hemostatic plug?

A

Adherence
Shape change
Secretion
Aggregation
Contract

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6
Q

How long does platelet production take place?

A

4-5 days

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7
Q

What is the circulation time of a platelet?

A

7-9 days

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8
Q

What is the lifespan of platelets?

A

10 vdays

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9
Q

The major determinant of platelet density is based on the

A

alpha granules of the platelets

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10
Q

PF-1 =

A

Factor V

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11
Q

PF-2 =

A

anti-ATIII

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12
Q

PF-4 =

A

neut & monocyte chemotactic factor & anti-heparin

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13
Q

PF-5 =

A

Fibrinogen

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14
Q

PF-6 =

A

Antiplasmin

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15
Q

Beta-thrombospondin binds

A

fibrinogen

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16
Q

Beta-thromboglobulin impedes

A

PGI2 production by the endothelium

17
Q

Fibronectin is…

A

an adhesin in wound healing
aka opsonin

18
Q

vWF/Factor I are binding proteins for

A

adhesion/cohesion

19
Q

Define emperipolesis.

A

The active penetration of one cell by another which remains intact

20
Q

What diseases of the thrombon are possible?

A
  • Thrombocytopaenia
  • thrombocytopathies
  • thrombocytosis
  • primary bone marrow disease
  • reactive
  • essential thrombocytosis
21
Q

What are some clinical signs of thrombocytopaenia?

A
  • prolonged bleeding after a minor cut or wound
  • bleeding defect in newborns
  • access to poisons
  • purpura
  • bleeding into body cavity, muscle, eye
  • decrease in platelet numbers
22
Q

What are the 3 mechanisms of thrombocytopenia?

A
  • Deficient production
  • Accelerated destruction or loss
  • abnormal pooling
23
Q

Viremia infection causing thrombocytopenia is often…

A

M3 hyperplasia of bone marrow megakaryocytes

24
Q

Rickettsial infection causing thrombocytopenia often causes…

A
  • stem-cell suppression or myelofibrosis
  • splenic sequestration
  • consumption due to vasculitis
25
Q

Babesia canis leading to thrombocytopenia casues…

A

hepatic &splenic sequestration due to hepatosplenomegaly

26
Q

Other specific causes…

A

Hemolymphatics (21 decks)

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