Verapamil, diltiazem

Question 1

Class

Answer 1

Rate limiting CCB’s

Question 2

Mechanism

Answer 2

Rate limiting: Inhibit calcium influx into cardiac myocytes -> negative ionotropy

Question 3

Indications

Answer 3

• Angina, HTN, Arrythmias

Question 4

SE

Answer 4

Common: Lack of energy

Important: Sino-atrial and AV block with diltiazem, particularly in those taking digoxin and/or beta blockers

Question 5

CI

Answer 5

• HF, Heart block

Question 6

Interactions

Answer 6

• Beta blockers (asystole, severe hypotension, heart failure)
• Anti-arrhythmics (increased risk of bradycardia, AV block and myocardial depression)