Digoxin Flashcards

1
Q

Class

A

Cardiac glycosides

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2
Q

Mechanism

A
  1. Inhibits sodium potassium ATPase
  2. Prolongs phase 4 of cardiac AP
  3. Increase preload -> + Inotropic, - chronotropic
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3
Q

Indications

A
  • Rate control
  • Heart failure
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4
Q
A
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5
Q

SE

A

Digoxin toxicity; narrow therapeutic window

Confusion

GI upset

Evidence of cardiotoxicity – palpitations, arrhythmias, conduction disturbances

Blurred or yellow vision

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6
Q

CI

A
  • Sick sinus syndrome
  • Bradycardia (Heart block)
  • WPW, Vtach, Vfib
  • Hypokalaemia, hypercalcaemia
  • Previous MI
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