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Pharmacology > Potassium sparing diuretics (Aldosterone antagonist) > Flashcards

Potassium sparing diuretics (Aldosterone antagonist) Flashcards

1
Q

Examples

A
  • Aldosterone antagonist: Spirinolactone, Eplerenone
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2
Q

Indications

A
  • Oedema in congestive heart failure – shown to improve survival
  • Ascites
  • Primary hyperaldosteronism
  • Nephrotic syndrome
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3
Q

Mechanism

A
  • Inhibits intracellular aldosterone receptor -> Inhibit Na/Cl reabsorption & K+ secretion
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4
Q

SE

A

Common: Hyperkalaemia (less commonly hyponatraemia and hyperuricaemia)

Important: Gynaecomastia/hypogonadism, impotence in males, menstrual irregularities

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5
Q

CI

A
  • Renal impairment
  • Avoid in hyperkalaemia, hyponatraemia, anuria and Addison’s disease
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Pharmacology (44 decks)

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