Mesalazine (5-Amino-salicylic-acid) Flashcards
1
Q
Class
A
- Aminosalicylates (5-ASA)
2
Q
Mechanism
A
- COX Inhibitor -> decrease PG
3
Q
Indications
A
- Induction and maintenance of remission of ulcerative colitis
- Induction of remission of Crohn’s disease
- Rheumatoid arthritis (Sulfasalazine only, under expert guidance)
4
Q
SE
A
Common: GI upset (diarrhoea, nausea, vomiting, abdominal pain)
Important: Acute pancreatitis; Blood disorders including agranulocytosis; Lupus erythematosus-like syndrome (sulfasalazine); Renal dysfunction
5
Q
CI
A
- Elderly, pregnancy and breastfeeding, patients with a history of asthma and those with hepatic or renal impairment (avoid if severe)
- Caution with SULFASALAZINE in patients with G6PD deficiency – observe closely for signs of haemolytic anaemia
6
Q
Monitoring
A
- Check renal Fn, FBC - Stop aminosalicylate if it is suspected that the patient has developed a blood issue