Mesalazine (5-Amino-salicylic-acid) Flashcards

1
Q

Class

A
  • Aminosalicylates (5-ASA)
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2
Q

Mechanism

A
  • COX Inhibitor -> decrease PG
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3
Q

Indications

A
  • Induction and maintenance of remission of ulcerative colitis
  • Induction of remission of Crohn’s disease
  • Rheumatoid arthritis (Sulfasalazine only, under expert guidance)
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4
Q

SE

A

Common: GI upset (diarrhoea, nausea, vomiting, abdominal pain)

Important: Acute pancreatitis; Blood disorders including agranulocytosis; Lupus erythematosus-like syndrome (sulfasalazine); Renal dysfunction

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5
Q

CI

A
  • Elderly, pregnancy and breastfeeding, patients with a history of asthma and those with hepatic or renal impairment (avoid if severe)
  • Caution with SULFASALAZINE in patients with G6PD deficiency – observe closely for signs of haemolytic anaemia
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6
Q

Monitoring

A
  • Check renal Fn, FBC - Stop aminosalicylate if it is suspected that the patient has developed a blood issue
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