Metformin Flashcards

1
Q

Class

A
  • Biguanides
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2
Q

Mechanism

A
  • Activate AMPK:

Inhibits gluconeogenesis, increase insulin sensitivty

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3
Q

Indications

A
  • First line therapy in overweight patients (BMI>25) with type II diabetes mellitus (who have failed on diet/exercise measures)
  • Adjuvant therapy in normal weight patients (BMI<25) who do not achieve adequate glycaemic control on sulphonylureas
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4
Q

SE

A

Common: Weight loss, vomiting

Important: lactic acidosis

N.B. does NOT affect the secretion of insulin – it only increases the body’s response to the insulin which is already present

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5
Q

CI

A
  • Ketoacidosis, Renal impairment - increased risk lactic acidosis
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6
Q

Interactions

A

ACE I; increased hypoglycaemic effect

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