Metformin Flashcards
1
Q
Class
A
- Biguanides
2
Q
Mechanism
A
- Activate AMPK:
Inhibits gluconeogenesis, increase insulin sensitivty
3
Q
Indications
A
- First line therapy in overweight patients (BMI>25) with type II diabetes mellitus (who have failed on diet/exercise measures)
- Adjuvant therapy in normal weight patients (BMI<25) who do not achieve adequate glycaemic control on sulphonylureas
4
Q
SE
A
Common: Weight loss, vomiting
Important: lactic acidosis
N.B. does NOT affect the secretion of insulin – it only increases the body’s response to the insulin which is already present
5
Q
CI
A
- Ketoacidosis, Renal impairment - increased risk lactic acidosis
6
Q
Interactions
A
ACE I; increased hypoglycaemic effect