PPI's Flashcards
1
Q
Examples
A
- Omeprazole, lanzoprazole
2
Q
Mechanism
A
- Irreversible inhibition (H+K+ATpase) proton pump in stomach -> Decreases acid secretion
3
Q
Indications
A
- Peptic ulcers
- Helicobacter pylori eradicaton (omeprazole, clarithromycin, metronidazole/amoxicillin)
- GORD
4
Q
Side effects
A
Common: GI upset, headache
Important: Rebound acid hypersecretion - increase HCl after, PPI, Hepatitis, Interstitial nephritis, Blood disorders (leucopenia, leucocytosis, pancytopenia, thrombocytopenia) Increased risk of Clostridium difficile infection, hypomagnesaemia
5
Q
Contraindications
A
- Masks gastric cancer
- Pregnancy/breast-feeding
6
Q
Interaction
A
- Warfarin (Omeprazole and esomeprazole increase anticoagulant effect)
- Clopidogrel (Omeprazole and esomeprazole may reduce antiplatelet effect)
