Thiazide diuretics Flashcards
1
Q
Examples
A
- Thiazide diuretics: Bendroflumethiazide, hydrochlorothiazide
- Thiazide-like diuretics: Indapamide, metolazone
2
Q
Mechanism
A
- Inhibits Na/Cl symporter in the DCT -> Stop transport out of lumen -> Hyperosmotic lumen -> Diuresis
3
Q
Indications
A
- HTN, Oedema
4
Q
SE
A
- Hypercholesterolaemia, gout
- Hypokalaemia, hyponatraemia, hypomagnesaemia
- Hypercalcaemia, hyperglycaemia
Important: Impotence
5
Q
CI
A
- Renal impairment, gout, DM
- Electrolyte imbalances