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Pharmacology > Synthetic glucocorticoids > Flashcards

Synthetic glucocorticoids Flashcards

1
Q

Examples

A
  • Hydrocortisone (cortisol), prednisone, dexamethasone
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2
Q

Mechanism

A
  • Bind to intracellular inhibitor
  • Inhibit Phospholipase A2 & COX -> Stop arachidonic acid & PG synthesis [mimics endogenous cortisol]
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3
Q

Indications

A
  • Suppression of inflammatory and allergic disorders (IBD, asthma, RA)
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4
Q

SE

A
  • Infections/immunosupression; decrease WBC due to decrease cytokines
  • Cushings/osteoporosis
  • Addison’s (if stopped - supression HPA)
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5
Q

CI

A
  • Pregnancy, immunosupressed
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6
Q

Monitoring

A

Do NOT stop suddenly - addison’s

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Pharmacology (44 decks)

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