Vasculitis

Question 1

What is vasculitis

Answer 1

Inflammation of the blood vessels with schema, necrosis, organ inflammation

Question 2

what type of vessel can it affect

Answer 2

arteries, arterioles, veins, venules or capillaries

Question 3

Is primary vasculitis idiopathic?

Answer 3

Yup can be

Question 4

What can secondary vasculitis be triggered by

Answer 4

infection, drug, toxin

Question 5

What are the 2 main types of large vessel vasculitis called?

Answer 5

takayasu arteritis and giant cell arteritis

Question 6

What does takayasu most commonly affect

Answer 6

women under 40 in asia

Question 7

What age group does GCA affect

Answer 7

over 50 and causes temporal arteritis

Question 8

What is commonly found with large vessel vasculitis

Answer 8

bruit, BP, claudication, hypertension, tenderness of vessel

Question 9

Is there an association with polymyalgia rheumatic and temporal arteritis

Answer 9

yes

Question 10

what are symptoms of temporal arteritis

Answer 10

headache, jaw claudication, scalp tenderness, prominent temporal artery

Question 11

What investigations are used with temporal arteritis

Answer 11

ESR, viscosity, CRP, biopsy

Question 12

What is the gold standard treatment of temporal arteritis

Answer 12

prednisolone low dose, steroids may be used sparingly

Question 13

What are 2 conditions seen in medium vessel disease and what do they affect commonly

Answer 13

kawasaki disease and polyarteritis nodosa- both affect kidneys, gut and skin and associated with Hep B

Question 14

What is kawasaki disease

Answer 14

occurs in children under 5, affects coronary arteries

Question 15

What is polyarteritis nodosa

Answer 15

necrotising inflammatory lesions resulting in aneurysm formation

Question 16

What are the ANCA associated small vessel diseases

Answer 16

granulomatosis with polyangiitis, eosinophilic granulomatosis with polyangiitis and microscopic polyangiitis

Question 17

What is granulomatosis with polyangiitis formerly known as and what happens?

Answer 17

Wegeners, inflammation of respiratory tract.

Question 18

What is churg strauss syndrome now called, and what does it do

Answer 18

Eosinophilic granulomatosis with polyangiitis and inflammation of respiratory tract

Question 19

What age does G with polyangiitis occur at and what are some symptoms

Answer 19

35-55 and mouth ulcers, sinusitis, cough, infiltrates, purpora, necrotising glomerulonephritis, conjunctivitis, uveitis

Question 20

Is asthma associated with eosinophilic granulomatosis with polyangiitis?

Answer 20

110%

Question 21

What criteria is for diagnosing eosinophilic GPA

Answer 21

asthma, eosinophilia >10% in blood, paranasal sinusitis, infiltrates, polyneuropathy

Question 22

What is used to detect ANCAS in blood?

Answer 22

immunofluorescence

Question 23

cANCA is what

Answer 23

granulomatosis with polyangiitis

Question 24

what is pANCA

Answer 24

eosinophilic GPA

Question 25

What is management of vasculitis

Answer 25

methotrexate and steroids (azathioprine and steroids), cyclophosphamide and steroids if systemic

Question 26

What is henoch schonlein purpura

Answer 26

acute immunoglobulin A disorder, GI tract, respiratory tract, skin, joints affected

Question 27

What is the most common infection in HSP

Answer 27

Stop A

Question 28

What test is essential in HSP

Answer 28

urinalysis