Pain Flashcards
what is pain
an unpleasant emotional and sensory experience associated with tissue damage
What are the three types of pain
nociceptive, inflammatory, pathological
What are nociceptors stimulated by?
Intense stimuli that is noxious
What are nociceptors
peripheral primary sensory afferent neurones
Nociceptors are first order neurons that relay info to second order neurones in CNS, true or flase
true
Can nociceptors be stimulated by weal stimuli?
Hell-no- it has a high threshold thus only intense stimuli can provoke nociceptors
What is inflammatory pain?
Adaptive and protective
What is allodynia?
A stimuli that once didn’t produce pain or harm, but now does
Can inflammatory pain be healed by itself?
No, it normally requires medication or treatment of some sort
What is pathological pain?
Maladaptive with NO PROTECTION
How does pathological pain usually occur?
due to a malfunction somewhere in the nervous system
What are alpha delta fibres?
mechanical and thermal myelinated nociceptors. This is FIRST pain.
What are C fibre nociceptors?
unmyelinated receptors that respond to all stimuli thus bringing about a second pain
Where does transduction of nociceptors occur
free nerve endings
Describe the process of sensory neurones
stimulated by heat/ mechanical or chemical ways- open ion channels- depolarising receptor - amplitude of potential relative ti intensity of stimulus
What has an afferent and efferent function?
Peptidergic polymodal C fibre nociceptors
What does the peptide SP do?
vasosilation, extravasation of palm proteins, release cytokines and mast cells and sensitizes surrounding nociceptors
What is the transmitter between primary afferent and second order neurone?
glutamate
Where does C and alpha delta fibres terminate?
laminae 1 and 2
What is it called when ells receive input form only alpha delta fibres?
Proprioceptive
What 2 sysmtens ascends on the spinal cord
spinothalamic tract and spinoreticular tract
What neurones do the spinothalmic have
alpha delta
