UWORLD/FA Biochem

Question 1

in active skeletal muscle, what causes glycogenolysis?

Answer 1

Ca2+ levels being increased from muscle contraction

Question 2

what is targetted in colchine therapy for gout?

Answer 2

neutrophil chemotaxis via stopping MT formation

Question 3

what does MSUD and thiamine have to do with eachother?

Answer 3

MSUD is a problem in breaking down branched chain AA (val, leu, ile)
the enzyme responsible for the breakdown in alpha ketoacid dehydrogenase
it is dependent on thiamine as a cofactor

Question 4

what does ACTH have to do with EPI production?

Answer 4

NE becomes E in the adrenal medulla via PNMT (phenylethanolamine N methyl transferase).
PNMT concentrations are upregulated by cortisol, which is produced via ACTH stim

Question 5

HOMOCYSTINURIA

Answer 5

AR cystathione B synthase
needs B6 as cofactor
presents as: marfanoid, lens subluxation, thromboembolism, intellectual disability

Question 6

Riboflavin def affects what reaction

Answer 6

succinate dehydrogenase

succinate —-> fumarate

Question 7

where does the PPP pathway happen

Answer 7

mitochondria

Question 8

what do the mushrooms inhibit

Answer 8

RNA pol II (therefore mRNA synthesis

Question 9

whats the point of the ristocetin test?

Answer 9

no response to ristocetin, but yes aggregation upon adding plasma.. suggests VWF def