Basic Pathology Flashcards
1
Q
ALK
A
R TyrK
lungadenocarcinoma
oncogene
2
Q
BCR ABL
A
TyrK
CML, ALL
oncogene
3
Q
BCL2
A
anti-apoptotic molecule
follicular and diffuse large b cell lymphoma
oncogene
4
Q
BRAF
A
Ser/Threonine Kinase
Melanoma, non-Hodgekin Lymphoma, papillary thyroid ca
oncogene
5
Q
cKIT
A
cytokine receptor
GIST
oncogene
6
Q
cMYC
A
TF
Burkitt’s Lymphoma
oncogene
7
Q
Her2/ney
A
RTyrK
Breast Ca& Gastric Ca
oncogene
8
Q
JAK2
A
TyrK
chronic myeloprolif disorders
oncogene
9
Q
KRAS
A
GTPase
Colon Ca, Pancreatic Ca, Lung Ca
oncogene
10
Q
MYCL1
A
TF
Lung ca
oncogene
11
Q
MYCN
A
TF
Neuroblastoma
oncogene
12
Q
RET
A
RtyrK
MEN2a MEN 2b
medullary thyroid ca
oncogene
13
Q
APC
A
tumor supressor gene
B catenin/wnt pathway
CRC assn w/ FAP
14
Q
BRCA1/BRCA2
A
tumor supressor gene
DNA repair
breast ca, ovarian ca, pancreatic ca
15
Q
CDKN2A
A
p16, blocks G1->S
Colon Ca
