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need to knows > Basic Pathology > Flashcards

Basic Pathology Flashcards

1
Q

ALK

A

R TyrK
lungadenocarcinoma
oncogene

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2
Q

BCR ABL

A

TyrK
CML, ALL
oncogene

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3
Q

BCL2

A

anti-apoptotic molecule
follicular and diffuse large b cell lymphoma
oncogene

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4
Q

BRAF

A

Ser/Threonine Kinase
Melanoma, non-Hodgekin Lymphoma, papillary thyroid ca
oncogene

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5
Q

cKIT

A

cytokine receptor
GIST
oncogene

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6
Q

cMYC

A

TF
Burkitt’s Lymphoma
oncogene

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7
Q

Her2/ney

A

RTyrK
Breast Ca& Gastric Ca
oncogene

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8
Q

JAK2

A

TyrK
chronic myeloprolif disorders
oncogene

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9
Q

KRAS

A

GTPase
Colon Ca, Pancreatic Ca, Lung Ca
oncogene

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10
Q

MYCL1

A

TF
Lung ca
oncogene

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11
Q

MYCN

A

TF
Neuroblastoma
oncogene

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12
Q

RET

A

RtyrK
MEN2a MEN 2b
medullary thyroid ca
oncogene

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13
Q

APC

A

tumor supressor gene
B catenin/wnt pathway
CRC assn w/ FAP

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14
Q

BRCA1/BRCA2

A

tumor supressor gene
DNA repair
breast ca, ovarian ca, pancreatic ca

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15
Q

CDKN2A

A

p16, blocks G1->S

Colon Ca

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16
Q

DCC

A

deleted in colon ca

17
Q

DPC4/SMAD4

A

deleted in pancreatic ca

18
Q

TP53

A

p53, activates p21, blocks G1->S

LiFraumeni SBLA= sarcoma, breast, leukemia, adrenal gland

need to knows (31 decks)

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