basic pharmacology

Question 1

tetrodotoxin

Answer 1

Pufferfish.

bind fast vgc Na- prevent depol

Question 2

ciguatoxin

Answer 2

reef fish: barracuda, snapper, eel
bind Na ch, cause depol
s(x)- reversal of hot/cold

Question 3

histamine (scrombroid)

Answer 3

dark meat fish- tuna, mahi mahi, mackeral, bonito

bacterial histidine decarboxylase makes histidine -> histamine therefore looks like ANAPHYLAXIS but needs antihistamines

Question 4

t(x) for toxicity of acetaminophen

Answer 4

N-acetylcysteine (replenishes glutathione)

Question 5

t(x) for toxicity of arsenic and mercury

Answer 5

diMERcaprol, succiMER

Question 6

t(x) for toxicity of benzodiazepine

Answer 6

flumazenil

Question 7

t(x) for toxicity of B blocker

Answer 7

glucagon, atropine

Question 8

t(x) for toxicity of CO

Answer 8

100% O2, hyperbaric O2

Question 9

t(x) for toxicity of Cu

Answer 9

Penacillamine (a Cu Penny) , Trientine

Question 10

t(x) for toxicity of cyanide

Answer 10

nitrite+thiosulfate, hydroxycobalamin

Question 11

t(x) for toxicity of heparin

Answer 11

protamine sulfate

Question 12

t(x) for toxicity of iron

Answer 12

deFERoxamine, deFERasirox, deFERprone

Question 13

t(x) for toxicity of lead

Answer 13

EDTA, diMERcaprol, succiMER, penicillamine

Question 14

t(x) for toxicity of methanol, ethylene glycol (anti-freeze)

Answer 14

Fomepizole> ethanol

Question 15

t(x) for toxicity of methemoglobin

Answer 15

methylene, vit C

Question 16

t(x) for toxicity of opoids

Answer 16

Naloxone

Question 17

t(x) for toxicity of salicylates and TCA

Answer 17

NaHCO3 to alkanize urine

Question 18

t(x) for toxicity of warfarin

Answer 18

vit K (slow), FFP (fast)

Question 19

what causes Torsades des Pointes

Answer 19

ABCDE
antiArrhythmics (class IA&III) 
antiBiotics (macrolides)
anti "C"ychotics (haloperidol) 
antiDepressants (TCAs) 
antiEmetics (odansetron)

Question 20

what causes Hyperglycemia

Answer 20

Taking Pills Necessitates Having blood Checked

Tacrolimus, Protease i, Niacin, HCTZ, Corticosteroids

Question 21

what causes SIADH

Answer 21

Can’t Concentrate Serum Sodium

Carbamazepine, Cyclophosphamide, SSRI

Question 22

what causes Hepatic Necrosis

Answer 22

liver “HAVAc”

Halothane, Amanita phalloides, Valproic A, Acetaminophen

Question 23

what causes pancreatitis

Answer 23

Drugs Causing A Violent Abdominal Distress

Didanosine, Corticosteroids, Alcohol, Valproic A, Azathioprine, Diuretics

Question 24

what causes Agranulocytosis

Answer 24

Can Cause Pretty Major Collapse of Granulocytes

Clozapine, Carbamazepine, Propythiouracil, Methimazole, Colcichine, Gancicylovir

Question 25

what causes aplastic anemia

Answer 25

Cant Make New Blood Cells Properly | Carbamazepine, Methimazole, NSAIDS, Benzene, Cholarmphenicol, Propylthiouracil

Question 26

what causes hemolysis in G6PD

Answer 26

hemolysis IS D PAIN | Isoniazid, Sulfonamides, Dapsone, Primaquine, Aspirin, Ibuprofen, Nitrofurantoin

Question 27

what causes megaloblastic anemia

Answer 27

HydroxYUrea, Phenytoin, Methotrexate, Sulfa

Question 28

what causes fat redistribution

Answer 28

Protease Inhibitors, glucocorticoids

Question 29

what causes gout

Answer 29

Painful Tophi and Feet Need Care | Pyrazinamide, Thiazide, Furosemide, Niacin, Cyclosporine

Question 30

what causes photo sensitivity

Answer 30

SAT For photo | sulfonamides,amiodarone, tetracyclines, 5FU

Question 31

what causes Stevens Johnson

Answer 31

Antiepilleptics (lamotrgine) Allopurinol Sulfa Penicillin

Question 32

what causes SLE like syndrome

Answer 32

``` Lupus is SHIPP-E Sulfa Hydralazine Isoniazid Phentyoin Procainamide Etanercept ```

Question 33

what causes seizures

Answer 33

``` w/ seizures I BITE (my tongue) Isoniazide Buproprion Imipenem/cilastin Tramadol Enflurane ```

Question 34

what causes Parkinson -like syndrome

Answer 34

A.R.M. Antipsychotics Reserpine Metoclopramide

Question 35

what causes Pulmonary Fibrosis

Answer 35

``` My Nose Cannot Breathe Bad Air Methotrexate Nitrofurantoin Carmustine Bleomycin Busulfan Amiodarone ```

Question 36

what causes Disulfiram like reaction

Answer 36

``` Sorry Pals Cant Go Mingle Sulfonylurea Procarbazine Cephalosporins GriseSulfavin Metronidazole (if taken w/ EtOH) ```

Question 37

CYTOCHROME P450 INDUCERS (+)

Answer 37

``` CHRONIC ALCOHOLICS STeal PHEN-PHEN and NEVer REFuse GReasy CARBs chronic alcoholics st. johns wart phenobarbital phenytoin Nevirapine rifampin Griseofulvin carbamazepine ```

Question 38

CYTOCHROME P450 INHIBITORS (-)

Answer 38

``` SICKFACES.COM Sodium Valproate Isoniazid Cemitidine Ketoconazole Fluconazole Acute Alcohol Abuse* Chloramphenicol Erythromycin Sulfonamides Ciprofloxacin Omeprazole Metronidazole ```

Question 39

Name the Sulfa drugs

Answer 39

``` Scary Sulfa Pharm FACTS sulfonamide antibiotics sulfasalazine Probenecid Furosemide Acetazolamide Celecoxib Thiazide Sulfonylurea ```

Question 40

CYP 450 substrates

Answer 40

``` Always Think When Outdoors Anti-epileptics Theophylline Warfarin OCPs ```