Unit 4 Part 1 - Clinical Chemistry Flashcards
study of chemical components of the body in plasma or serum
clinical chemistry
3 groups of clinical chemistry in the lab
- routine chemistry
- routine chemistry urinalysis
- special chemistry
types of specimens in chemistry
blood (serum or plasma) – not RBC except for HgbA1C
urine
feces
CSF
sweat
hair
stones
first department to be automated
chemistry
benefits of automation
reduced medical errors
reduced sample volume
improved safety
faster TAT
step 1 in automated analysis
make sure specimen is properly collected
step 2 in automated analysis
instrument is programed to measure proper amount of specimen and reagent to yield a final conc
most of the automation is based on
photometry
step 3 in automated analysis
chemical reaction causes sample to change color
part of the instrument that measures how much light will pass through the sample
spectrophotometer
a reaction that results in a dark color would allow __ light to pass through, which means __ result
less, higher
a reaction that results in a light color would allow __ light to pass through, which means __ result
more, lower
blood glucose will produce a __ color after chemical reaction with a reagent
blue
dark blue color indicates ___ glucose result
high
medium blue color indicates ___ glucose result
normal
light blue color indicates ___ glucose result
low
step 4 in automated analysis
instrument programmed to measure the absorbance and give result
step 5 in automated analysis
reading results and see if it falls within certain parameters
machines test hundreds - thousands of ___ per hour
tests NOT specimens (1 patient can have more than 1 test done)
testing in this department includes processes used to detect levels of enzymes, suagrs, proteins, and otehr substances in the blood in order to determine conditions
clinical chemistry
formed by hgb breakdown, increased in liver damage
bilirubin
end product of protein metabolism and is excreted by the kidneys, increased in kidney damage
urea
measures the lipids in the body
cholesterol & triglycerides
metabolic waste, increase indicates kidney damage
creatinine