U-World Cytokines Flashcards
Cytokine:
IL-1
Major Secretion Source?
Major Effects?
Major Secretion Source:
- Macrophages
Major Effects
- ↑ Neutrophil and macrophage migration
- ↑ Acute phase reactants
- Causes Fever and Shock
ILCytokine:
IL-2
Major Secretion Source?
Major Effects?
Major Secretion Source:
- T Cells
Major Effects
- ↑ T Cell activation and proliferation
- ↑ NK cell and macrophage activity
- ↑ B Cell Growth
Cytokine:
IL-3
Major Secretion Source?
Major Effects?
Major Secretion Source:
- T Cells
Major Effects
- ↑ Hematopoiesis
Cytokine:
IL-4
Major Secretion Source?
Major Effects?
Major Secretion Source:
- TH2 Cells
Major Effects
- ↑ TH2 Cell Differentiation
- ↑ B Cell Growth
- ↑ Isotype Switching to IgE
Cytokine:
IL-5
Major Secretion Source?
Major Effects?
Major Secretion Source:
- TH2 Cells
Major Effects
- ↑ Differentiation of Eosinophils
- ↑ Isotype Switching to IgA
Cytokine:
IL-6
Major Secretion Source?
Major Effects?
Major Secretion Source:
- Macrophages
Major Effects
- ↑ T Cell Growth
- ↑ B Cell Growth
- ↑ Osteoclast activity
- ↑ Acute phase reactants
- Causes Fever
Cytokine:
IL-8
Major Secretion Source?
Major Effects?
Major Secretion Source:
- Macrophages
- T Cells
Major Effects
- ↑ Neutrophil activation and Chemotaxis
Cytokine:
IL-10
Major Secretion Source?
Major Effects?
Major Secretion Source:
- TH2 Cells
Major Effects
- ↓ TH1 Cell Differentiation
- ↓ Cell mediated immunity and APC activity
- ↑ B Cell Function
Cytokine:
IL-12
Major Secretion Source?
Major Effects?
Major Secretion Source:
- Macrophages
Major Effects
- ↑ TH1 Cell differentiation
- ↑ NK cell and CD8+ T Cell activity
Cytokine:
IFN-Y
Major Secretion Source?
Major Effects?
Major Secretion Source:
- TH1 Cells
- NK Cells
Major Effects
- ↑ Intracellular killing by macrophages
- ↑ MHC I and MHC II expression
- ↑ TH1 Cell differentiation
Cytokine:
TGF-Beta
Major Secretion Source?
Major Effects?
Major Secretion Source:
- Most Cell Types
Major Effects
- ↓ Immune cell function
- ↑ Matrix synthesis and angiogenesis
Cytokine:
GM-CSF
Major Secretion Source?
Major Effects?
Major Secretion Source:
- T Cells
- Macrophages
Major Effects
- ↑ Growth and differentiation of myeloid progenitors
Cytokine:
TNF-Alpha
Major Secretion Source?
Major Effects?
Major Secretion Source:
- Macrophages
Major Effects
- ↑ Inflammation and Cell-mediated immunity
- ↑ Acute phase reactants
- Causes fever and shock
