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--Step Shit-- > Lipid enzymes and Components > Flashcards

Lipid enzymes and Components Flashcards

1
Q

What is the role of:

Hepatic lipase

A

Degrades TG’s remaining in IDL

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2
Q

What is the role of:

Hormone sensitive lipase

A

Degrades TG’s stored in adipocytes

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3
Q

What is the role of:

Lecithin-cholesterol acyltransferase

A

Catalyzes Esterification of 2/3rd of plasma cholesterol

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4
Q

What is the role of:

Lipoprotein lipase

A

Degrades TG’s circulating chylomicrons and VLDLs.

Found on vascular endothelial surface

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5
Q

What is the role of:

Pancreatic lipase

A

Degrades dietary TG’s in small intestine

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6
Q

What is the function of:

Apolipoprotein E

A

Mediates remnant uptake

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7
Q

What is the function of:

Apolipoprotein A-1

A

Activates LCAT

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8
Q

What is the function of:

Apolipoprotein C-II

A

Lipoprotein lipase cofactor that catalyzes cleavage

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9
Q

What is the function of:

Apolipoprotein B-48

A

Mediates chylomicron secretion into lymphatics

only on particles originating from intestines

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10
Q

What is the function of:

Apolipoprotein B-100

A

Binds LDL receptor

only on particles originating from liver

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11
Q

What lipoproteins contain: ( 5 )

Apolipoprotein E

A 
Chylomicron
Chylomicron remnant
VLDL
IDL
HDL
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12
Q

What lipoproteins contain: ( 1 )

Apolipoprotein A-1

A

HDL

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13
Q

What lipoproteins contain: ( 3 )

Apolipoprotein C-II

A

Chylomicron
VLDL
HDL

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14
Q

What lipoproteins contain: ( 2 )

Apolipoprotein B-48

A

Chylomicron

Chylomicron remnant

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15
Q

What lipoproteins contain: ( 3 )

Apolipoprotein B-100

A

VLDL
IDL
LDL

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16
Q

What is the role of:

Cholesterol

A

Needed to maintain cell membrane integrity

Needed to synthesize bile acid, steroids, and vitamin D

17
Q

What is the role of:

Chylomicrons

A

Delivers dietary TGs to peripheral tissues

Delivers cholesterol to liver in the form of chylomicron remnants, which are mostly depleted of their TGs

(Secreted by intestinal epithelial cells)

18
Q

What is the role of:

VLDL

A

Delivers hepatic TGs to peripheral tissue

Secreted by liver

19
Q

What is the role of:

IDL

A

Formed in the degradation of VLDL

Delivers TGs and cholesterol to liver

20
Q

What is the role of:

LDL

A

Delivers hepatic cholesterol to peripheral tissues

Formed by hepatic lipase modification of IDL in the liver and peripheral tissue

Taken up by target cells via receptor-mediated endocytosis

21
Q

What is the role of:

HDL

A

Mediates reverse cholesterol transport from periphery to liver

Acts as a repository for apolipoproteins C and E (which are needed for chylomicron and VLDL metabolism)

Alcohol Increases its synthesis

(Secreted from both liver and intestine)

--Step Shit-- (32 decks)

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