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--Step Shit-- > Important First Aid Cytokines > Flashcards

Important First Aid Cytokines Flashcards

1
Q

Secreted by all T Cells

A

IL-2

IL-3

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2
Q

IL-12

A

Induces differentiation of T cells into Th-1 Cells

Activates NK cells

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3
Q

IL-8

A

Major chemotactic factor for neutrophils

Also induces phagocytosis in Neutrophil once it arrives

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4
Q

TNF-a

A

Activates Endothelium
Causes WBC Recruitment
Causes Vascular leaking
Causes cachexia in malignancy ( influence on hypothalamus that leads to appetite suppression, inhibiting LPL and inc insulin resist in periph tissues)
Maintains Granulomas in TB
Can mediate Sepsis
Causes insulin resistance (by phosphorylating serine and threonine residues of insulin receptor and insulin receptor substrate)

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5
Q

IL-2

A

Stimulates growth of helper, cytotoxic, and regulatory T cells
Stimulates growth of NK cells
Also stimulates growth of B cells and activation of NK cells and Monocytes

First IL produced by T cell after antigen contact
(receptor for IL 2 acts via jak stat)

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6
Q

IL 1-6 Pneumonic

A 
Hot T-Bone stEAK
IL-1: Fever (hot)
IL-2: Stimulates T cell (T)
IL-3: Stimulates bone marrow (bone)
IL-4: Stimulates IgE production (E)
IL-5: Stimulates IgA production (A)
IL-6: Stimulates aKute phase protein production (K)
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7
Q

Cytokines from Th1 Cells

A

INF-Y

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8
Q

IL-4

A 
Induces differentiation of T cells into Th2 cells
Promotes growth of B cells
Enhances class switching to IgE and IgG
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9
Q

INF-Y

A

Secreted by NK cells and T cells in response to antigen or IL-12 from macrophages
Stimulates macrophages to kill phagocytosed pathogens
Inhibits differentiation of Th2 Cells
Activates NK cells to kill virus infected cells
Increases MHC expression and antigen presentation by all cells (inhances viral and parasitic resistance)

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10
Q

Secreted by Macrophages

A 
IL-1
IL-6
IL-8
IL-12
TNF-a
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11
Q

IL-10

A

Attenuates inflammatory response
Dec Expression of MHC class II and Th1 Cytokines
Inhibits activated macrophages and dendritic cells
Also secreted by regulatory T cells

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12
Q

IL-6

A

Fever
Stimulates production of Acute phase proteins
Can Mediate sepsis

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13
Q

IL-5

A

Promotes growth and differentiation of B cells
Enhances class switching to IgA
Stimulates growth and differentiation of eosinophils

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14
Q

Cytokines From Th2 Cells

A

IL-4
IL-5
IL-10

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15
Q

IL-3

A

Supports growth and differentiation of bone marrow stem cells
(functions like GM-CSF)

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16
Q

TGF-B

A

Attenuates immune response with IL-10

17
Q

IL-1

A

Fever
Acute inflammation
Activates endothelium to express adhesion molecules
Induces chemokine secretion to recruit WBC’s
Can Mediate Sepsis

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