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Oncogenes/Tumor Suppressor Genes Flashcards

1
Q

What is the gene type/product/and associated neoplasms for:

ALK

A

Gene Type: Oncogene

Gene Product:
Receptor tyrosine kinase

Associated Neoplasms:
Lung Adenocarcinoma

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2
Q

What is the gene type/product/and associated neoplasms for:

BCR-ABL

A

Gene Type: Oncogene

Gene Product:
Tyrosine Kinase

Associated Neoplasms:
CML and AML

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3
Q

What is the gene type/product/and associated neoplasms for:

BCL-2`

A

Gene Type: Oncogene

Gene Product:
Anti Apoptotic molecule

Associated Neoplasms:
Follicular and diffuse Large B cell lymphomas

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4
Q

What is the gene type/product/and associated neoplasms for:

BRAF

A

Gene Type: Oncogene

Gene Product:
Serine/Threonine kinase

Associated Neoplasms:
Melanoma, Non-Hodgkin lymphoma, Papillary thyroid carcinoma

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5
Q

What is the gene type/product/and associated neoplasms for:

c-KIT

A

Gene Type: Oncogene

Gene Product:
Cytokine Receptor

Associated Neoplasms:
Gastrointestinal stromal tumor

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6
Q

What is the gene type/product/and associated neoplasms for:

c-MYC

A

Gene Type: Oncogene

Gene Product:
Transcription Factor

Associated Neoplasms:
Burkitt Lymphoma

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7
Q

What is the gene type/product/and associated neoplasms for:

HER2/neu (c-erbB2)

A

Gene Type: Oncogene

Gene Product:
Receptor Tyrosine Kinase

Associated Neoplasms:
Breast and Gastric Carcinoma

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8
Q

What is the gene type/product/and associated neoplasms for:

JAK2

A

Gene Type: Oncogene

Gene Product:
Tyrosine Kinase

Associated Neoplasms:
Chronic myeloproliferative disorders (not CML)

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9
Q

What is the gene type/product/and associated neoplasms for:

KRAS

A

Gene Type: Oncogene

Gene Product:
GTPase

Associated Neoplasms:
Colon, Lung, Pancreatic cancer

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10
Q

What is the gene type/product/and associated neoplasms for:

MYCL1

A

Gene Type: Oncogene

Gene Product:
Transcription factor

Associated Neoplasms:
Lung tumor

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11
Q

What is the gene type/product/and associated neoplasms for:

N-myc(MYCN)

A

Gene Type: Oncogene

Gene Product:
Transcription factor

Associated Neoplasms:
Neuroblastoma

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12
Q

What is the gene type/product/and associated neoplasms for:

RET

A

Gene Type: Oncogene

Gene Product:
Receptor tyrosine kinase

Associated Neoplasms:
MEN 2A, MEN 2B, Papillary thyroid carcinoma

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13
Q

What is the gene type/product/and associated neoplasms for:

APC

A

Gene Type: Tumor Suppressor

Gene Product:
Negative regulator of B-catenin/WNT pathway

Associated Neoplasms:
Colorectal cancer (assoc w/ FAP)
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14
Q

What is the gene type/product/and associated neoplasms for:

BRCA1/BRCA2

A

Gene Type: Tumor Suppressor

Gene Product:
DNA repair protein

Associated Neoplasms:
Breast, Ovarian, Pancreatic cancers

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15
Q

What is the gene type/product/and associated neoplasms for:

CDKN2A

A

Gene Type: Tumor Suppressor

Gene Product:
p16, blocks G1 –>S phase

Associated Neoplasms:
Melanoma and pancreatic cancer

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16
Q

What is the gene type/product/and associated neoplasms for:

DCC

A

Gene Type: Tumor Suppressor

Gene Product:
Deleted in colon cancer (DCC)

Associated Neoplasms:
Colon Cancer

17
Q

What is the gene type/product/and associated neoplasms for:

SMAD4 (DPC4)

A

Gene Type: Tumor Suppressor

Gene Product:
DPC (deleted in pancreatic cancer)

Associated Neoplasms:
Pancreatic cancer

18
Q

What is the gene type/product/and associated neoplasms for:

MEN 1

A

Gene Type: Tumor Suppressor

Gene Product:
menin

Associated Neoplasms:
MEN 1

19
Q

What is the gene type/product/and associated neoplasms for:

NF 1

A

Gene Type: Tumor Suppressor

Gene Product:
Neurofibromin (Ras GTPase activating protein)

Associated Neoplasms:
NF 1

20
Q

What is the gene type/product/and associated neoplasms for:

NF 2

A

Gene Type: Tumor Suppressor

Gene Product:
Merlin (schwannomin) protein

Associated Neoplasms:
NF 2

21
Q

What is the gene type/product/and associated neoplasms for:

PTEN

A

Gene Type: Tumor Suppressor

Gene Product:
Negatively regulates PI3k/AKT pathway

Associated Neoplasms:
Breast, Prostate, and endometrial cancer

22
Q

What is the gene type/product/and associated neoplasms for:

Rb

A

Gene Type: Tumor Suppressor

Gene Product:
Inhibits E2F; blocks G1 –> S phase

Associated Neoplasms:
Retinoblastoma and osteosarcoma

23
Q

What is the gene type/product/and associated neoplasms for:

TP53

A

Gene Type: Tumor Suppressor

Gene Product:
P53; activates p21, blocks G1–> S phase

Associated Neoplasms:
Most human cancers and Li- Fraumeni syndrome (SBLA- Sarcoma, Breast, Leukemia, Adrenal glands)

24
Q

What is the gene type/product/and associated neoplasms for:

TSC 1

A

Gene Type: Tumor Suppressor

Gene Product:
Hamartin protein

Associated Neoplasms:
Tuberous sclerosis

25
Q

What is the gene type/product/and associated neoplasms for:

TSC 2

A

Gene Type: Tumor Suppressor

Gene Product:
Tuberin Protein

Associated Neoplasms:
Tuberous sclerosis

26
Q

What is the gene type/product/and associated neoplasms for:

VHL

A

Gene Type: Tumor Suppressor

Gene Product:
Inhibits hypoxia inducible factor 1a

Associated Neoplasms:
VHL

27
Q

What is the gene type/product/and associated neoplasms for:

WT1

A

Gene Type: Tumor Suppressor

Gene Product:
Transcription factor regulating urogenital development

Associated Neoplasms:
Wilms Tumor (nephroblastoma)

--Step Shit-- (32 decks)

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