Oncogenes/Tumor Suppressor Genes

Question 1

What is the gene type/product/and associated neoplasms for:

ALK

Answer 1

Gene Type: Oncogene

Gene Product:
Receptor tyrosine kinase

Associated Neoplasms:
Lung Adenocarcinoma

Question 2

What is the gene type/product/and associated neoplasms for:

BCR-ABL

Answer 2

Gene Type: Oncogene

Gene Product:
Tyrosine Kinase

Associated Neoplasms:
CML and AML

Question 3

What is the gene type/product/and associated neoplasms for:

BCL-2`

Answer 3

Gene Type: Oncogene

Gene Product:
Anti Apoptotic molecule

Associated Neoplasms:
Follicular and diffuse Large B cell lymphomas

Question 4

What is the gene type/product/and associated neoplasms for:

BRAF

Answer 4

Gene Type: Oncogene

Gene Product:
Serine/Threonine kinase

Associated Neoplasms:
Melanoma, Non-Hodgkin lymphoma, Papillary thyroid carcinoma

Question 5

What is the gene type/product/and associated neoplasms for:

c-KIT

Answer 5

Gene Type: Oncogene

Gene Product:
Cytokine Receptor

Associated Neoplasms:
Gastrointestinal stromal tumor

Question 6

What is the gene type/product/and associated neoplasms for:

c-MYC

Answer 6

Gene Type: Oncogene

Gene Product:
Transcription Factor

Associated Neoplasms:
Burkitt Lymphoma

Question 7

What is the gene type/product/and associated neoplasms for:

HER2/neu (c-erbB2)

Answer 7

Gene Type: Oncogene

Gene Product:
Receptor Tyrosine Kinase

Associated Neoplasms:
Breast and Gastric Carcinoma

Question 8

What is the gene type/product/and associated neoplasms for:

JAK2

Answer 8

Gene Type: Oncogene

Gene Product:
Tyrosine Kinase

Associated Neoplasms:
Chronic myeloproliferative disorders (not CML)

Question 9

What is the gene type/product/and associated neoplasms for:

KRAS

Answer 9

Gene Type: Oncogene

Gene Product:
GTPase

Associated Neoplasms:
Colon, Lung, Pancreatic cancer

Question 10

What is the gene type/product/and associated neoplasms for:

MYCL1

Answer 10

Gene Type: Oncogene

Gene Product:
Transcription factor

Associated Neoplasms:
Lung tumor

Question 11

What is the gene type/product/and associated neoplasms for:

N-myc(MYCN)

Answer 11

Gene Type: Oncogene

Gene Product:
Transcription factor

Associated Neoplasms:
Neuroblastoma

Question 12

What is the gene type/product/and associated neoplasms for:

RET

Answer 12

Gene Type: Oncogene

Gene Product:
Receptor tyrosine kinase

Associated Neoplasms:
MEN 2A, MEN 2B, Papillary thyroid carcinoma

Question 13

What is the gene type/product/and associated neoplasms for:

APC

Answer 13

Gene Type: Tumor Suppressor

Gene Product:
Negative regulator of B-catenin/WNT pathway

Associated Neoplasms:
Colorectal cancer (assoc w/ FAP)

Question 14

What is the gene type/product/and associated neoplasms for:

BRCA1/BRCA2

Answer 14

Gene Type: Tumor Suppressor

Gene Product:
DNA repair protein

Associated Neoplasms:
Breast, Ovarian, Pancreatic cancers

Question 15

What is the gene type/product/and associated neoplasms for:

CDKN2A

Answer 15

Gene Type: Tumor Suppressor

Gene Product:
p16, blocks G1 –>S phase

Associated Neoplasms:
Melanoma and pancreatic cancer

Question 16

What is the gene type/product/and associated neoplasms for:

DCC

Answer 16

Gene Type: Tumor Suppressor

Gene Product:
Deleted in colon cancer (DCC)

Associated Neoplasms:
Colon Cancer

Question 17

What is the gene type/product/and associated neoplasms for:

SMAD4 (DPC4)

Answer 17

Gene Type: Tumor Suppressor

Gene Product:
DPC (deleted in pancreatic cancer)

Associated Neoplasms:
Pancreatic cancer

Question 18

What is the gene type/product/and associated neoplasms for:

MEN 1

Answer 18

Gene Type: Tumor Suppressor

Gene Product:
menin

Associated Neoplasms:
MEN 1

Question 19

What is the gene type/product/and associated neoplasms for:

NF 1

Answer 19

Gene Type: Tumor Suppressor

Gene Product:
Neurofibromin (Ras GTPase activating protein)

Associated Neoplasms:
NF 1

Question 20

What is the gene type/product/and associated neoplasms for:

NF 2

Answer 20

Gene Type: Tumor Suppressor

Gene Product:
Merlin (schwannomin) protein

Associated Neoplasms:
NF 2

Question 21

What is the gene type/product/and associated neoplasms for:

PTEN

Answer 21

Gene Type: Tumor Suppressor

Gene Product:
Negatively regulates PI3k/AKT pathway

Associated Neoplasms:
Breast, Prostate, and endometrial cancer

Question 22

What is the gene type/product/and associated neoplasms for:

Rb

Answer 22

Gene Type: Tumor Suppressor

Gene Product:
Inhibits E2F; blocks G1 –> S phase

Associated Neoplasms:
Retinoblastoma and osteosarcoma

Question 23

What is the gene type/product/and associated neoplasms for:

TP53

Answer 23

Gene Type: Tumor Suppressor

Gene Product:
P53; activates p21, blocks G1–> S phase

Associated Neoplasms:
Most human cancers and Li- Fraumeni syndrome (SBLA- Sarcoma, Breast, Leukemia, Adrenal glands)

Question 24

What is the gene type/product/and associated neoplasms for:

TSC 1

Answer 24

Gene Type: Tumor Suppressor

Gene Product:
Hamartin protein

Associated Neoplasms:
Tuberous sclerosis

Question 25

What is the gene type/product/and associated neoplasms for:

TSC 2

Answer 25

Gene Type: Tumor Suppressor

Gene Product:
Tuberin Protein

Associated Neoplasms:
Tuberous sclerosis

Question 26

What is the gene type/product/and associated neoplasms for:

VHL

Answer 26

Gene Type: Tumor Suppressor

Gene Product:
Inhibits hypoxia inducible factor 1a

Associated Neoplasms:
VHL

Question 27

What is the gene type/product/and associated neoplasms for:

WT1

Answer 27

Gene Type: Tumor Suppressor

Gene Product:
Transcription factor regulating urogenital development

Associated Neoplasms:
Wilms Tumor (nephroblastoma)