Autoantibodies and Associated Disorders

Question 1

Anti-SSA (Anti-Ro)

Answer 1

Sjogren Syndrome

Question 2

Anti-CCP

Answer 2

Rheumatoid Arthritis (more specific)

Question 3

lupus anticoagulant

Answer 3

SLE, antiphospholipid syndrome

Question 4

Antithryoglobulin

Answer 4

Hashimoto thyroiditis

Question 5

Anti-smooth muscle

Answer 5

Autoimmune Hepatitis Type 1

Question 6

Anti Helicase (anti-Mi-2)

Answer 6

Polymyositis, dermatomyositis

Question 7

Anti-glutamic acid decarboxylase

Answer 7

Type 1 diabetes mellitus

Question 8

Anti-hemidesmosome

Answer 8

Bullous pemphigoid

Question 9

Antiparietal cell

Answer 9

Pernicious anemia

Question 10

Anticentromere

Answer 10

Limited scleroderma (CREST syndrome)

Question 11

Anti-intrinsic factor

Answer 11

Pernicious anemeia

Question 12

Anti-dsDNA

Answer 12

SLE

Question 13

Anti-presynaptic voltage gated calcium channel

Answer 13

Labert-Eaton myasthenic syndrome

Question 14

IgA anti-tissue transglutaminase

Answer 14

Celiac Disease

Question 15

Anti-thyroid peroxidase

Answer 15

Hashimoto thyroiditis

Question 16

Anti-U1 RNP (ribonucleoprotein)

Answer 16

Mixed Connective Tissue Disease

Question 17

Anti-Scl-70 (anti-DNA topoisomerase 1)

Answer 17

Diffuse Scleroderma

Question 18

Anti-SRP

Answer 18

Polymyositis, dermatomyositis

Question 19

Anitmitochondrial

Answer 19

Primary biliary cirrhosis

Question 20

Antiphospholipase A2 receptor

Answer 20

Primary membranous nephropathy

Question 21

Rheumatoid factor (IgM antibody against IgG Fc region)

Answer 21

Rheumatoid Arthritis

Question 22

Anticardiolipin

Answer 22

SLE, antiphospholipid syndrome

Question 23

Anti-Smith

Answer 23

SLE

Question 24

IgA anti-endomysial

Answer 24

Celiac Disease

Question 25

Antinuclear (ANA)

Answer 25

Nonspecific screening antibody often associated with SLE (and also seen in drug induced lupus)

Question 26

MPO-ANCA/p-ANCA

Answer 26

Microscopic polyangiitis Eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome) Ulcerative colitis

Question 27

Anti-SSB (Anti-La)

Answer 27

Sjogren Syndrome

Question 28

Anti-β2 glycoprotein

Answer 28

Antiphospholipid syndrome

Question 29

Antimicrosomal

Answer 29

Hashimoto thyroiditis

Question 30

Antisynthetase (eg. anti-Jo-1 or anti-histidyl-tRNA synthetase)

Answer 30

Polymyositis, dermatomyositis

Question 31

Islet cell cytoplasmic antibodies

Answer 31

Type 1 diabetes mellitus

Question 32

Anti-TSH receptor

Answer 32

Graves Disease

Question 33

Anti-ACh receptor

Answer 33

Myasthenia gravis

Question 34

PR3-ANCA/c-ANCA

Answer 34

Granulomatosis with polyangiitis (Wegener)

Question 35

Anti-desmoglein (1 and 3) (anti-desmosome)

Answer 35

Pemphigus vulgaris

Question 36

Anti-Histone

Answer 36

Drug Induced Lupus

Question 37

Anti-glomerular basement membrane

Answer 37

Goodpasture syndrome