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--Step Shit-- > General Drugs: Toxicity Treatments > Flashcards

General Drugs: Toxicity Treatments Flashcards

1
Q

Acetaminophen

A

N-acetylcysteine (replenishes glutathione)

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2
Q

AChE inhibitors/Organophosphates

A

Atropine and Pralidoxime

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3
Q

Antimuscarinics/Anticholinergic agents

A

Physostigmine, and control hyperthermia

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4
Q

Arsenic

A

Dimercaprol, succimer

(Arsenic binds to sulfhydryl and blocks 3 things: cell respiration [pyruvate dehydrogenase], gluconeogenesis, and glutathione metabolism)
(Sulfhydryl of dimercaprol combines with arsenic and displaces them from the enzymes of cellular respiration)

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5
Q

Benzodiazepines

A

Flumazenil (competitive)

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6
Q

B-Blockers

A

Atropine, Glucagon

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7
Q

Carbon Monoxide

A

100% O2, hyperbaric O2

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8
Q

Copper

A

Penicillamine, Trientine

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9
Q

Cyanide

A

Nitrite + thiosulfate, Hydroxocobalamin

(cyanide binds fe3+ in cytochrome c oxidase inhibiting ETC)
(Thiosulfate provides additional sulfur groups to rhodanese enzyme which forms cyanide into thiocyanate)
(Nitrite forms methemoglobin)
( Hydroxocobalamin [b12 precursor] binds cyanide to form cyanocobalamin which can be excreted in urine)

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10
Q

Digitalis (digoxin)

A

Anti-dig Fab Fragments

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11
Q

Heparin

A

Protamine Sulfate

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12
Q

Iron

A

Deferoxamine, Deferasirox, Deferiprone

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13
Q

Lead

A

EDTA, Dimercaprol, Succimer, Penicillamine
(Succimer in children or mild lead toxicities)
(EDTA and Succimer in Adults)
(Penicillamine is third line)
(EDTA forms non ionizing salts which inc urinary lead)
(Dimercaprol has forms stable nontoxic soluble chelates to remove heavy metals in urine, but it itself is toxic w/ narrow TI, cause nephrotoxicity and HTN)

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14
Q

Mercury

A

Dimercaprol, Succimer

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15
Q

Methanol, ethylene glycol (antifreeze)

A

Fomepizole > ethanol, dialysis

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16
Q

Opioids

A

Naloxone

17
Q

Salicylates

A

NaHCO3 (alkalinize urine), dialysis

18
Q

TCAs

A

NaHCO3 (alkalinize urine)

19
Q

Warfarin

A

Vitamin K (takes time), Fresh Frozen Plasma (immediate)

20
Q

Methemoglobin

A

Methylene Blue, Vitamin C

(MBlue acts as artificial electron transporter for methemoglobin reduction through NADPH pathway to non enzymatically reduce Fe3 to Fe2)

--Step Shit-- (32 decks)

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